中国临床药学杂志2025，Vol.34Issue(10)：726-733,8.DOI:10.19577/j.1007-4406.2025.10.002
上海市郊区成人慢性阻塞性肺疾病患者用药模式研究
A study of medication patterns in adult patients with chronic obstructive pulmonary disease in suburban Shanghai
摘要
Abstract
AIM To understand medication patterns among adults with chronic obstructive pulmonary disease(COPD)in suburban Shanghai.METHODS Based on the Shanghai Suburban Adult Cohort and Biobank(SSACB),952 COPD patients in 2023 were selected as study subjects.Demographic information,lifestyle and other related data were obtained based on face-to-face questionnaires;consultation and medication information were obtained based on the cohort regional health information sharing platform.Microsoft Excel 2021 was used to establish the database,and the statistical analysis was done in SPSS 20.0.RESULTS The total hospital visiting number of the study population was 1 433 and the proportions of outpatient,emergency and inpatient were 63.7％,16.8％and 19.5％respectively.Among the study population,19.9％used only one COPD medication,while 39.0％required more than 4 medications.Notably,88.0％of patients were concurrently using at least one comorbidity medication.The top 4 COPD medications used(in order of prevalence)were,inhaled corticosteroids(ICS)(55.3％),expectorants(54.0％),long-acting β2 agonists(LABA)(50.3％),and systemic corticosteroids(SCS)(43.6％).The proportions of men using medications for the 5 categories,such as short-acting β2 agonists(SABA),long-acting muscarinic antagonist(LAMA),methylxanthines,SCS and expectorants were higher(P＜0.05).The proportions of women using medications for the 5 comorbidities of diabetes,hyperlipidemia,osteoporosis,anemia,and depression/anxiety were higher than these of men(P＜0.05).The ordinal regression analysis revealed that male patients(OR=1.59,95％CI:1.17-2.16)and higher comorbidity medication counts(OR=1.32,95％CI:1.18-1.49)independently predicted increased number of COPD medications(P＜0.05).CONCLUSION The medication patterns of the study subjects are complex,and there are gender and comorbidity differences.It is recommended that these factors be fully considered in the management of COPD in order to facilitate the development of individualized therapeutic strategies,enhance precision management,and improve patient prognosis.关键词
慢性阻塞性肺疾病/用药模式/性别差异/合并症Key words
chronic obstructive pulmonary disease/medication pattern/sex difference/comorbidity分类
临床医学引用本文复制引用
白海凡,王娜,赵根明,杨其莲,付朝伟..上海市郊区成人慢性阻塞性肺疾病患者用药模式研究[J].中国临床药学杂志,2025,34(10):726-733,8.基金项目
复旦闵行康联体项目(编号2023FM06) （编号2023FM06）
