中国临床药学杂志2025，Vol.34Issue(10)：748-753,6.DOI:10.19577/j.1007-4406.2025.10.005
伏立康唑骨水泥链珠的制备及体外释放研究
Research on preparation and release of voriconazole bone cement in vitro
摘要
Abstract
AIM To investigate the in vitro release pattern of voriconazole bone cement beads,to provide reference for clinical application.METHODS Voriconazole from different doses and manufacturers was added to bone cement to make bone cement chain beads.The sampling time points were set by the isometric leaching method,the concentration of the leaching solution was measured by ultra-performance liquid chromatography-tandem mass spectrometry to observe the release pattern of voriconazole bone cement beads.RESULTS The cumulative release rates of 600,800,and 1 000 mg voriconazole added to bone cement after 28 days were(44.00±4.33)％,(34.16±2.34)％,and(28.40±2.08)％.The release patterns followed the Weibull equation lnln[1/(1-F)]=0.349 8 ln t-2.667 7(r=0.992 3).The overall release rate of voriconazole in bone cement with sodium sulfonamide-β-cyclodextrin was higher than that of voriconazole with hydroxypropyl-β-cyclodextrin,and the difference was statistically significant(P＜0.05).CONCLUSION Voriconazole bone cement chain beads have certain sustained-release properties.Adding 600 mg of voriconazole to 40 g of bone cement is a more suitable ratio.Voriconazole supplemented with sodium sulfonamide-β-cyclodextrin has a higher release rate when added to bone cement.关键词
伏立康唑/骨水泥/体外释放/真菌/骨与关节感染Key words
voriconazole/bone cement/in vitro release/fungus/bone and joint infection分类
药学引用本文复制引用
毛璐,林平,智博洋..伏立康唑骨水泥链珠的制备及体外释放研究[J].中国临床药学杂志,2025,34(10):748-753,6.基金项目
首都医科大学附属北京积水潭医院人才培养"学科骨干"计划(编号XKGG202206) （编号XKGG202206）
