中国实用儿科杂志2025，Vol.40Issue(10)：813-818,6.DOI:10.19538/j.ek2025100604
儿童神经重症中的目标体温管理
Targeted temperature management in pediatric neurocritical care
周利兵 1柏振江1
作者信息
- 1. 苏州大学附属儿童医院重症医学科,江苏 苏州 215025
- 折叠
摘要
Abstract
Targeted Temperature Management(TTM)is a crucial neuroprotective strategy in pediatric neurocritical care,yet several key problems remain unresolved in its clinical application.Due to immature neurological development,high metabolic rates,and weak thermoregulation,children are more susceptible to secondary brain injury mediated by mitochondrial dysfunction,oxidative stress,and neuroinflammatory responses following acute neurological insults.TTM may exert neuroprotective effects by reducing cerebral metabolism,suppressing inflammation,and inhibiting apoptosis.However,the optimal implementation protocol(e.g.,target temperature,duration,rewarming rate)and the risk-benefit ratio in specific populations require further validation through large-scale clinical studies and long-term follow-up.关键词
目标体温管理/儿童/神经保护Key words
targeted temperature management/child/neuroprotection分类
医药卫生引用本文复制引用
周利兵,柏振江..儿童神经重症中的目标体温管理[J].中国实用儿科杂志,2025,40(10):813-818,6.
