中国中药杂志2025，Vol.50Issue(20)：5632-5640,9.DOI:10.19540/j.cnki.cjcmm.20250710.501
黄芪桂枝五物汤治疗糖尿病周围神经病变的机制研究进展
Research progress on mechanism of Huangqi Guizhi Wuwu Decoction in treating diabetic peripheral neuropathy
摘要
Abstract
Diabetic peripheral neuropathy(DPN)is a common complication of diabetes,characterized by a complex pathogenesis for which no specific mechanism has yet been clearly identified.Studies have shown that the onset and progression of DPN are mainly associated with inflammation,oxidative stress,autophagy dysfunction,lipid metabolism disorders,iron metabolism disturbances,and vascular lesions.Clinically,commonly used therapeutic agents primarily focus on nourishing nerves and improving microcirculation,including mecobalamin,gangliosides,inositol,and ginkgolide glycosides.However,no curative treatment is currently available,and drug therapies generally show unsatisfactory efficacy.According to traditional Chinese medicine(TCM),DPN falls under the categories of"blood impediment"and"impediment syndrome",and is considered to result from the failure of the sinews and vessels to receive proper nourishment,leading to numbness in the limbs.The underlying pathogenesis is attributed to Qi deficiency and blood stasis.Therefore,TCM offers distinct advantages in the treatment of DPN and has achieved favorable therapeutic outcomes.TCM therapies are characterized by multi-target,multi-pathway mechanisms and low incidence of side effects,making them suitable for managing chronic diseases such as DPN.Huangqi Guizhi Wuwu Decoction,recorded in the Synopsis of the Golden Chamber(Jin Gui Yao Lue),is a representative classical prescription for treating blood impediment.It functions to regulate and tonify Qi and blood and to warm and unblock the meridians and collaterals,which aligns well with the fundamental TCM pathogenesis of Qi stagnation and blood stasis in DPN.Recent research has shown that Huangqi Guizhi Wuwu Decoction can exert therapeutic effects on DPN through pathways including antioxidative stress,anti-inflammatory responses,inhibition of cell apoptosis,and improvement of microcirculation.These effects have been validated not only in cell and animal studies but also in clinical trials,confirming its definite therapeutic efficacy for DPN.This study elucidates the pathogenesis of DPN from both TCM and modern biomedical perspectives,discusses the specific pathways and mechanisms by which Huangqi Guizhi Wuwu Decoction acts in the context of DPN,and elaborates on its mechanisms at both molecular and formula levels.This study is expected to provide a theoretical and practical reference for future TCM-based prevention and treatment strategies for DPN,as well as for the development of novel therapeutic agents.关键词
黄芪桂枝五物汤/糖尿病周围神经病变/作用机制Key words
Huangqi Guizhi Wuwu Decoction/diabetic peripheral neuropathy/mechanism引用本文复制引用
韩欣园,刘长清,孙晨曦,王瑾..黄芪桂枝五物汤治疗糖尿病周围神经病变的机制研究进展[J].中国中药杂志,2025,50(20):5632-5640,9.基金项目
2022年丁元庆全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
山东中医药大学2023年度继续教育教学研究项目(FXLZ2023-05) （FXLZ2023-05）
2024年度山东省中医药科技项目(MR20241740) （MR20241740）
