摘要
Abstract
Objective:To evaluate the correlation between thyrotropin receptor antibody(TRAb)levels and thyroid diseases,so as to clarify its clinical application value in the diagnosis and treatment of thyroid diseases.Methods:This study was a retrospective cohort study,including 4 472 patients who visited the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from March 2016 to March 2024.Patients were divided into three groups based on their initial serum TRAb levels:L1 group(TRAb<1.75 IU/L),L2 group(1.75 IU/L≤TRAb<5.25 IU/L),and L3 group(TRAb≥5.25 IU/L).Basic information,laboratory test results,TCM syndromes,diagnostic information,and follow-up data after one year were collected.Spearman correlation analysis was used to understand the correlation between TRAb levels and other thyroid function indicators.The chi-square test was used to compare the prevalence of thyroid diseases at initial diagnosis and follow-up among different subgroups.Logistic regression analysis was used to determine the correlation between TRAb levels and the risk of thyroid diseases.ROC curves were used to assess the predictive value of baseline TRAb levels for the occurrence of thyroid diseases.Results:Patients with elevated TRAb levels predominantly had Qi(气)-Yin(阴)deficiency syndrome and phlegm-stasis intermingling syndrome in TCM.TRAb levels were significantly positively correlated with FT3,FT4,T3,TG,TGAb,and TPOAb(P<0.001).With increasing TRAb levels,the prevalence rates of Graves'hyperthyroidism,thyroid-associated ophthalmopathy,thyroid-related cardiopathy,and hyperthyroid liver damage were significantly increased(P<0.001).ROC curve analysis showed that TRAb levels had good predictive value for the occurrence of Graves'hyperthyroidism,hyperthyroid liver injury,and hyperthyroid-related complications(P<0.001).Conclusion:There is a significant positive correlation between TRAb and multiple key thyroid function indicators.High TRAb levels can serve as an early warning indicator for the occurrence of hyperthyroidism-related complications.Dynamic monitoring of TRAb levels is clinically significant for the diagnosis and treatment of thyroid diseases.关键词
促甲状腺激素受体抗体/甲状腺疾病/相关性分析Key words
Thyrotropin receptor antibody/Thyroid diseases/Correlation analysis分类
医药卫生
