中医临床研究2025，Vol.17Issue(23)：61-68,8.DOI:10.3969/j.issn.1674-7860.2025.23.010
中药治疗术后谵妄的Meta分析
A Meta-analysis of traditional Chinese medicine in the treatment of postoperative delirium
摘要
Abstract
Objective:This study systematically evaluated the clinical efficacy and safety of Chinese medicines in the treatment of postoperative delirium(POD),providing a basis for its application in the clinic.Methods:In PubMed,CNKI,Cochrane Library,Thieme database and Wanfang medical network,the journal literature on the treatment of POD with Chinese medicines since the establishment of the database was retrieved.The literature type was limited to randomized controlled trial(RCT).Strict inclusion and exclusion criteria were adopted.Through literature quality evaluation,Revman 5.3 analysis software was applied to conduct quantitative comprehensive analysis of the included literature.Results:Twenty-four articles(1 202 cases in the treatment group and 1 205 cases in the control group,totaling 2 407 cases)were included in the study.Meta-analysis of these articles showed that the effective rate of Chinese medicines in the treatment of POD was higher than that of Western medicine[RR=1.06,95%CI(1.02,1.11),Z=3.12,P=0.002(<0.05)].Furthermore,the prevention efficacy of Chinese medicines on POD was more significant than Western medicine[RR=0.43,95%CI(0.34,0.53),Z=7.59,P<0.000 01].Adverse clinical reactions during Chinese medicines treatment were lower than those of Western medicine[RR=0.39,95%CI(0.22,0.71),Z=3.12,P=0.002(<0.05)].There was no evident heterogeneity among the studies,thus the fixed effect model was used for analysis.Conclusion:Traditional Chinese medicine can be used as an auxiliary drug for the treatment of POD and has better clinical efficacy.Compared with the Western medicine,Chinese medicines have greater advantages in prevention of POD and has certain safety.However,there is publication bias in the included literature,and lack of application of syndrome differentiation and treatment of traditional Chinese medicine.The research conclusions need to be further verified by more rigorous designed large sample,multi-center,low bias randomized clinical controlled trials.关键词
术后谵妄/中药/中医/Meta分析Key words
Postoperative delirium/Chinese medicine/Traditional Chinese medicine/Meta-analysis分类
医药卫生引用本文复制引用
靳锐,敖勇峰..中药治疗术后谵妄的Meta分析[J].中医临床研究,2025,17(23):61-68,8.基金项目
内蒙古包头市科技计划项目(2020Z1014-1). （2020Z1014-1）
