北京中医药2025，Vol.44Issue(9)：1129-1134,6.DOI:10.16025/j.1674-1307.2025.09.009
针刀干预对制动诱导腓肠肌纤维化大鼠踝关节功能的作用观察
Effects of acupotomy intervention on the improvement of ankle function in rats with immobilization-induced gastrocnemius fibrosis
摘要
Abstract
Objective To observe the effects of acupotomy intervention on ankle dorsiflexion angle,hindlimb grip strength,gait,muscle contractility,and the length and weight of bilateral gastrocnemius muscles in rats with immobilization-induced gastrocnemius fibrosis.Methods Forty male Wistar rats were randomly divided into a blank group,a model group,an acupuncture group,and an acupotomy group,with 10 rats in each group.The right ankle joints of rats in the model,acupuncture,and acupotomy groups were fixed in the plantar-flexed position for 4 weeks to establish a gastrocnemius fibrosis model.After successful modeling,rats in the acupuncture and acupotomy groups received one corresponding intervention,followed by 10 days of stretching.After all treatments were completed,the ankle dorsiflexion angle,hindlimb grip strength,gait,muscle contractility,and the length and weight of bilateral gastrocnemius muscles were measured.Results Compared with the blank group,the model group showed smaller ankle dorsiflexion angle,lower hindlimb grip strength,shorter stride length,smaller paw area,shorter ground contact time,weaker twitch and tetanic contraction forces,shorter length and lower weight of the affected gastrocnemius muscle(P<0.05),as well as greater paw resistance and longer swing time(P<0.05).Compared with the model group,the acupotomy group showed significantly larger ankle dorsiflexion angle,higher hindlimb grip strength,longer stride length,larger paw area,longer ground contact time,stronger twitch and tetanic contraction forces,longer length and greater weight of the affected gastrocnemius muscle(P<0.05),as well as smaller paw resistance and shorter swing time(P<0.05).Compared with the acupuncture group,the acupotomy group showed significantly larger ankle dorsiflexion angle,higher hindlimb grip strength,larger paw area,longer ground contact time,stronger twitch and tetanic contraction forces,and longer affected gastrocnemius muscle(P<0.05),as well as smaller paw resistance and shorter swing time(P<0.05).There were no significant differences in the length and weight of bilateral gastrocnemius muscles between the blank group and the acupotomy group(P>0.05).In the model group,significant differences were found between the two sides in both muscle length and weight(P<0.05).In the acupuncture group,there was no significant difference in muscle length between sides(P>0.05),but a significant difference in muscle weight was observed(P<0.05).Conclusion Acupotomy can significantly improve ankle dorsiflexion angle,hindlimb grip strength,gait,and muscle contractility in rats with gastrocnemius fibrosis,while preventing compensatory overuse of the contralateral limb due to impairment of the affected muscle.关键词
骨骼肌纤维化/腓肠肌纤维化/针刀/踝关节功能/肌肉收缩性能Key words
skeletal muscle fibrosis/gastrocnemius muscle fibrosis/acupotomy/ankle joint function/muscle contractility引用本文复制引用
张晗,李宛容,卢美璇,李佳慧,胡芮,赵欣韧,张义..针刀干预对制动诱导腓肠肌纤维化大鼠踝关节功能的作用观察[J].北京中医药,2025,44(9):1129-1134,6.基金项目
北京中医药大学校级科研横向发展基金项目(BUCM-2024-JS-ZX-008) （BUCM-2024-JS-ZX-008）
