南方医科大学学报2025，Vol.45Issue(11)：2358-2364,7.DOI:10.12122/j.issn.1673-4254.2025.11.08
针刀松解对腕管综合征兔正中神经及腕横韧带的影响
Effect of needle-knife release on the median nerve and transverse carpal ligament in rabbits with carpal tunnel syndrome
摘要
Abstract
Objective To investigate the effect of needle knife release on median nerve(MN)and transverse carpal ligament(TCL)morphology and function and expression levels of inflammatory factors in rabbit models of carpal tunnel syndrome(CTS).Methods Thirty adult New Zealand rabbits were randomized equally into control group,CTS model group,ultrasound-guided needle knife release group,needle knife release group without ultrasound guidance,and sham treatment groups.In all but the control group,the rabbits were subjected to CTS modeling by 10%glucose solution injection into the carpal tunnel once a week for 4 consecutive weeks,followed by interventions with a single treatment session.At 3 days and 30 days after the interventions,3 rabbits from each group were selected for ultrasound measurement of TCL and MN thickness,electrophysiological testing,ultrasound elastography,and inflammatory cytokine level assessment.Results In the rabbit models of CTS,ultrasound-guided needle knife release significantly reduced the thickness of TCL and MN and improved sensory nerve conduction velocity at both 3 and 30 days after the intervention.Elastography of the TCL showed markedly softened intra-carpal tissues after ultrasound-guided needle knife release and achieved superior outcomes over those in the other groups.The treatment also significantly reduced IL-17 levels and lowered IL-6 and PGE2 expression at 30 days after the intervention.Conclusion Needle knife release of the TCL reduces thickness of the MN and TCL,enhances median nerve function,alleviates intrascatic tissue stiffness,and downregulates inflammatory factors in the carpal tunnel in rabbit models of CTS,and ultrasound guidance further enhances its therapeutic efficacy.关键词
针刀松解/腕管综合征/腕横韧带/正中神经/超声引导Key words
needle-knife releas/carpal tunnel syndrome/transverse carpal ligament/median nerve/ultrasonic guidance引用本文复制引用
李蕴楠,周俏吟,罗申,林伟霖,黄馨瑶,曹莹..针刀松解对腕管综合征兔正中神经及腕横韧带的影响[J].南方医科大学学报,2025,45(11):2358-2364,7.基金项目
国家中医药管理局高水平中医药重点学科建设项目(中医骨伤科学,zyyzdxk-2023106) （中医骨伤科学,zyyzdxk-2023106）
福建中医药大学中医骨伤科学学科开放课题资助XGS2023019 （）
