赣南医科大学学报2025，Vol.45Issue(10)：957-960,4.DOI:10.3969/j.issn.2097-7174.2025.10.006
多西环素治疗8岁以下儿童耐药肺炎支原体肺炎可行性分析
Feasibility analysis of doxycycline in the treatment of drug-resistant mycoplasma pneumoniae pneumonia in children under 8 years old
摘要
Abstract
Objective:To explore the clinical efficacy and safety of doxycycline in the treatment of drug-resistant mycoplasma pneumoniae pneumonia(MPP)in children under 8 years old,and to analyze the safety of doxycycline used in young children.Methods:This study included children with drug-resistant MPP who were hospitalized in the pediatrics department of The First People's Hospital of Nankang from January 2024 to April 2025(116 cases),and their clinical data was collected.The patients were divided into control group(60 cases)and study group(56 cases).The control group were treated with azithromycin+methylprednisolone,while the study group were treated with doxycycline+methylprednisolone.Compare the therapeutic effects and adverse reactions of the two groups of children.Results:After clinical intervention,the fever remission time,the time of improvement of pulmonary signs,and the length of hospital stay in the study group were shorter than those in the control group,with statistical significance(P＜0.05).The treatment response of children in the study group was significantly better than that in the control group,with statistical significance(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups(P=0.909).Conclusion:The clinical efficacy of doxycycline combined with methylprednisolone in the treatment of drug-resistant MPP in children under 8 years old is significantly better than that of azithromycin.It can significantly shorten the time to fever resolution,the time to relief of pulmonary signs,and the length of hospital stay in children,and the incidence of adverse reactions of oral doxycycline treatment is low.关键词
多西环素/阿奇霉素/甲泼尼龙/肺炎支原体性肺炎,耐药性/儿童Key words
Doxycycline/Azithromycin/Methylprednisolone/Mycoplasma pneumoniae pneumonia,drug resistance/Children分类
医药卫生引用本文复制引用
伍先飞,赖重媛..多西环素治疗8岁以下儿童耐药肺炎支原体肺炎可行性分析[J].赣南医科大学学报,2025,45(10):957-960,4.基金项目
赣州市指导性科技计划项目(GZ2024ZSF415) （GZ2024ZSF415）
