广州医药2025，Vol.56Issue(10)：1311-1329,1345,20.DOI:10.20223/j.cnki.1000-8535.2025.10.001
智能可变形纳米载体的设计策略及其抗肿瘤应用研究进展
Recent development of smart deformable nanocarriers for antitumor application
摘要
Abstract
In recent years,drug delivery systems have made remarkable progress in the field of tumor-targeted therapy,with several platforms already approved for clinical use.Among them,nanomedicines have attracted considerable attention due to their ability to mitigate the side effects of conventional small-molecule chemotherapeutics,improve bioavailability,and passively accumulate at tumor sites via the enhanced permeability and retention(EPR)effect,thereby enhancing therapeutic efficacy.Of particular interest are stimuli-responsive,shape-transformable nanocarriers,which exhibit unique properties such as tunable size,tumor-specific accumulation,and structural adaptability in response to tumor-associated cues.These intelligent deformable nanocarriers are capable of undergoing various dynamic transformations—including aggregation,disassembly,size modulation,and morphological transitions—triggered by specific stimuli in the tumor microenvironment(TME),such as pH,redox potential,enzymes,or cytokines.Such transformations enhance drug retention at tumor sites,improve intratumoral penetration,and enable spatiotemporally controlled drug release,ultimately resulting in superior antitumor efficacy.For instance,nanosystems that shrink in size at tumor sites can promote deeper tissue penetration,while those that aggregate into larger assemblies can prolong local drug retention.Conversely,carriers that disassemble rapidly under tumor-specific stimuli allow for burst release of the encapsulated payload precisely at the disease site.These adaptive features hold great promise for improving the therapeutic performance of nanomedicines.Furthermore,the multifunctionality of intelligent deformable nanocarriers supports the development of personalized treatment regimens and combination therapies,offering novel strategies for cancer management.This review highlights recent advances in the design and application of shape-transformable nanocarriers for enhanced anticancer drug delivery,summarizing design principles and exploring their emerging potential in precision oncology.关键词
癌症治疗/智能变形纳米载体/药物递送/刺激响应Key words
cancer therapy/smart deformable nanocarriers/drug delivery/stimuli-responsive引用本文复制引用
郑允圣,谢建聪,曹紫洋..智能可变形纳米载体的设计策略及其抗肿瘤应用研究进展[J].广州医药,2025,56(10):1311-1329,1345,20.基金项目
广东省自然科学基金杰出青年项目(2024B1515020106) （2024B1515020106）
广州市第一人民医院科研启动项目(KY09050042) （KY09050042）
