海南医科大学学报2025，Vol.31Issue(21)：1672-1680,9.DOI:10.13210/j.cnki.jhmu.20250528.001
G蛋白偶联受体124在牙周细胞衰老中的潜在作用机制及研究进展
Potential mechanisms and research advances of G protein-coupled receptor 124 in periodontal cellular senescence
摘要
Abstract
G protein-coupled receptor 124 is an important member of the adhesion G protein-coupled receptor family.Peri-odontitis is a chronic inflammatory disease whose pathological mechanism stems from the multi-dimensional dynamic imbalance be-tween the microbial community and the host immune response system.Cellular senescence is characterized by cell cycle arrest,which may lead to tissue dysfunction when senescent cells persist and accumulate.There is a close relationship between cellular se-nescence and chronic inflammation,which is mainly realized through a senescence-associated secretory phenotype-mediated cas-cade of pro-inflammatory factors,forming a positive regulatory mechanism.This paper mainly reviews the potential mechanism of G protein-coupled receptor 124 in the process of periodontal cellular senescence,in order to provide a solid scientific basis and inno-vative ideas for regulating the inflammatory micro-environment of periodontal tissue.关键词
G蛋白偶联受体124/细胞衰老/牙周炎/衰老相关分泌表型Key words
G protein-coupled receptor 124/Cellular senescence/Periodontitis/SASP分类
口腔医学引用本文复制引用
林雪晶,董雨雷,崔明望,张淼淼,郭竹玲..G蛋白偶联受体124在牙周细胞衰老中的潜在作用机制及研究进展[J].海南医科大学学报,2025,31(21):1672-1680,9.基金项目
This study was supported by the National Natural Science Foundation of China(82201080),the Academic Promotion Support Program of Hainan Medical University(XSTS2025027) 国家自然科学基金青年科学基金项目(82201080) （82201080）
海南医科大学学术提升支撑计划(XSTS2025027) （XSTS2025027）
