湖南中医药大学学报2025，Vol.45Issue(11)：2149-2157,9.DOI:10.3969/j.issn.1674-070X.2025.11.017
"透毒培元"视角下胞葬作用与局部晚期鼻咽癌化疗敏感性的中医辨治策略
Efferocytosis and TCM pattern identification and treatment strategies for chemosensitivity in locally advanced nasopharyngeal carcinoma from the perspective of"expelling toxins and reinforcing yuan-primodial qi"
摘要
Abstract
Nasopharyngeal carcinoma(NPC)is a highly heterogeneous epithelial-derived malignant tumor with significant geographical aggregation,over 70%of patients with locally advanced disease at initial diagnosis.In TCM,it is classified under categories such as"true headache","nasal sinusitis",and"malignant tumor mass".The pathogenesis is generally attributed to"coagulation of toxin,blood stasis,and phlegm,with deficiency root and excess manifestation,"while its pattern identification often involves"heat-toxin accumulation and deficiency of both qi and yin."The therapeutic principle of"expelling toxins and reinforcing yuan-primodial qi"is proposed,with the core tenets being to dispel toxins,unblock obstructions,and strengthen the foundation to consolidate healthy qi.Efferocytosis is the process by which phagocytic cells clear apoptotic cells.In the tumor microenvironment,excessive efferocytosis can impair antigen presentation,limit immune activation,induce drug resistance,and promote immune evasion.Although concurrent chemoradiotherapy with platinum-based drugs remains the standard treatment for locally advanced NPC,challenges such as low chemosensitivity,immune evasion,and poor long-term survival rates still persist.The critical pathological link lies in immune silence caused by overactivation of efferocytosis in the tomor microenvironment.This paper focuses on the therapeutic principle of"expelling toxins and reinforcing yuan-primodial qi",integrating the efferocytosis to construct a pattern identification pathway that enhances chemosensitivity.It expands the theoretical and interventional dimensions of TCM in regulating the tumor immune microenvironment,providing novel insights for integrating Chinese and western medicine to optimize treatment outcomes for locally advanced NPC.关键词
胞葬作用/局部晚期鼻咽癌/铂类耐药/化疗敏感性/透毒培元/吞噬功能/免疫Key words
efferocytosis/nasopharyngeal carcinoma/platinum resistance/chemosensitivity/expelling toxins and reinforc-ing yuan-primodial qi/phagocytic function/immune分类
中医学引用本文复制引用
齐同飞,何兰,唐迎港,田道法,何迎春.."透毒培元"视角下胞葬作用与局部晚期鼻咽癌化疗敏感性的中医辨治策略[J].湖南中医药大学学报,2025,45(11):2149-2157,9.基金项目
国家自然科学基金项目(82305329) （82305329）
湖南省自然科学基金项目(2023JJ30449) （2023JJ30449）
长沙市自然科学基金项目(kq2208206) （kq2208206）
湖南省教育厅项目(23A0298) （23A0298）
湖南省卫生健康高层次人才重大专项项目(R2023111). （R2023111）
