华侨大学学报（自然科学版）2025，Vol.46Issue(6)：660-665,6.DOI:10.11830/ISSN.1000-5013.202510012
氧化透明质酸交联碳酰肼明胶/半胱氨酸壳聚糖复合水凝胶的制备及pH响应和抗氧化性能
Preparation of Oxidized Hyaluronic Acid Crosslinked Carbohydrazide-Gelatin/Cysteine-Chitosan Composite Hydrogel With pH-Responsive and Antioxidant Properties
摘要
Abstract
To enhance the biological functionality of natural polymer hydrogels,a pH-responsive composite hydrogel was designed and constructed based on oxidized hyaluronic acid(OHA),cysteine-grafted chitosan(CSCys),and carbonyl hydrazide-modified gelatin(Gel-CDH).The hydrogel achieved dynamic covalent crosslinking through Schiff base reactions between aldehyde groups and amino/hydrazide groups to form a sta-ble and tunable three-dimensional network structure.By adjusting the OH A ratio,three types of hydrogels were prepared,and their swelling behavior in relation to pH values as well as antioxidant activity were system-atically evaluated.The results showed that this composite hydrogel not only exhibited excellent pH responsive-ness but also demonstrated superior free radical scavenging capability due to the synergistic effects of functional groups such as thiol groups.关键词
水凝胶/壳聚糖/pH响应/抗氧化Key words
hydrogel/chitosan/pH-responsive/antioxidant分类
化学引用本文复制引用
于莹,彭永刚,李明春,辛梅华..氧化透明质酸交联碳酰肼明胶/半胱氨酸壳聚糖复合水凝胶的制备及pH响应和抗氧化性能[J].华侨大学学报（自然科学版）,2025,46(6):660-665,6.基金项目
福建省科技计划项目(2019H6014,2020Y4012) （2019H6014,2020Y4012）
