华侨大学学报（自然科学版）2025，Vol.46Issue(6)：685-693,9.DOI:10.11830/ISSN.1000-5013.202504039
ICIs时代晚期肾细胞癌幸存者的后续原发性癌症谱分析
Analysis of Subsequent Primary Cancer Spectrum in Survivors of Advanced Renal Cell Carcinoma in ICIs Era
摘要
Abstract
To assess the risk characteristics and influencing factors of subsequent primary cancers(SPCs)in survivors of advanced renal cell carcinoma(RCC)in the era of immune checkpoint inhibitors(ICIs)(November 2015-December 2021),standardized incidence ratios(RSi)and excess risks were calculated based on the SEER database,and 873 patients with advanced RCC were included.Analysis was performed stratified by gender and period before and after the COVID-19 epidemic.The results showed that patients with advanced RCC faced 50％higher solid tumors risks((95％CI:1.40-1.61),and excess risks were 63.89 people per 10 000 people in every year.The risks were higher in the female urinary system(bladder,RSi=2.39 in women,RSi=1.56 in men)and respiratory system(lung and bronchial cancer,RSi=1.57 in women,RSi=1.11 in men),however,the risks of the thyroid gland in males were higher(RSi=6.17 in men,RSi=5.41 in women).After the epi-demic,lung and bronchial cancers decreased significantly(RSi=1.12,P＞0.05),indicating delayed diagno-sis,while thyroid cancer remained at high risk(RSi=4.58).关键词
肾细胞癌/后续原发癌/免疫检查点抑制剂/标准化发病率Key words
renal cell carcinoma/subsequent primary cancer/immune checkpoint inhibitor/standardized inci-dence rate分类
临床医学引用本文复制引用
杨会勇,吴循循,黄思彬,马丽浩,苏兴豪,蔡亚设,史佳可,刘卓晟,狄彦君,刁勇..ICIs时代晚期肾细胞癌幸存者的后续原发性癌症谱分析[J].华侨大学学报（自然科学版）,2025,46(6):685-693,9.基金项目
福建省自然科学基金资助项目(2022J05062) （2022J05062）
福建省厦门自然科学基金资助项目(3502Z20227041) （3502Z20227041）
华侨大学中青年教师科技创项目(ZQN-PY319) （ZQN-PY319）
中央高校基本科研业务费资助项目(21BS126) （21BS126）
