湖南农业大学学报（自然科学版）2025，Vol.51Issue(5)：86-94,9.DOI:10.13331/j.cnki.jhau.2025.05.011
丙硫多菌灵在水稻中的残留及长期膳食摄入风险评估
Residue and long-term dietary intake risk assessment of albendazole in rice
摘要
Abstract
Standardized field residue trials of albendazole on rice were conducted in 12 locations including Hangzhou,Hefei,and Changsha in 2018,where a high-performance liquid chromatography method was established to determine its residues in rice,enabling qualitative and quantitative analysis.This study also investigated albendazole residue levels,degradation kinetics,and storage stability in rice,and evaluated the long-term dietary intake risks of its residues for different populations.The results showed that at spiking levels of 0.05,0.10,and 1.00 mg/kg,the average recovery rates of albendazole in rice ranged from 78%to 106%with relative standard deviations of 4%to 9%,and the limit of quantification was 0.05 mg/kg.Storage at-20℃for 24 weeks resulted in≤30%degradation across all rice samples.Its residue degradation in rice grains followed a first-order kinetic equation with half-lives of 8.66-11.55 days.Following three applications of a 10%albendazole suspension concentrate at an effective ingredient dosage of 150 g/hm2 with a 7-day application interval and pre-harvest intervals of 14 and 21 days,the final residues in brown rice,rice husk,rice grains,and rice straw were≤0.08,≤0.08,≤0.07,≤0.20 mg/kg,respectively.Risk assessments on dietary intake risks based on brown rice consumption patterns among different age and gender groups in China,Pakistan,India,Bangladesh,Argentina,and Thailand,as well as the total dietary intake risk in China yielded risk quotients below 100%,indicating acceptable long-term dietary exposure from brown rice consumption.关键词
丙硫多菌灵/水稻/残留量/储藏稳定性/膳食摄入风险评估Key words
albendazole/rice/residual amount/storage stability/dietary intake risk assessment分类
化学工程引用本文复制引用
谭敏仪,邓凯华,杨丽华,段菁菁,姚思敏,胡洋洋..丙硫多菌灵在水稻中的残留及长期膳食摄入风险评估[J].湖南农业大学学报（自然科学版）,2025,51(5):86-94,9.基金项目
湖南省自然科学基金项目(2023JJ50072) （2023JJ50072）
大学生创新创业训练计划项目(s202410537049) （s202410537049）
