华中科技大学学报（自然科学版）2025，Vol.53Issue(10)：49-53,5.DOI:10.13245/j.hust.251099
基于模板的rRNA二级结构可视化方法
Template-based visualizing method for rRNA secondary structure
摘要
Abstract
To address the challenge of generating standard 2D diagrams for ribosomal RNA secondary structures and the difficulty of directly performing sequence comparisons with the generated visualizations,a template-based rRNA splitting and drawing(RNA-SD)visualization method was proposed.By creating standard templates and splitting the entire sequence based on the characteristics of rRNA secondary structures,it was further mapped onto the standard template.This approach could not only generate high-quality rRNA secondary structure visualizations suitable for publication but also allow the extraction of any substructures for sequence comparison and statistical analysis.Experimental validation using over 1.4×104 metazoan mitochondrial genomes shows the feasibility and scalability of the proposed method.Compared to existing methods,the proposed method effectively categorizes and visualizes rRNA structures,supports sub-structure sequence comparison,and offers a powerful tool for large-scale rRNA comparative studies.关键词
RNA二级结构/RNA可视化/模板/序列拆分/序列比较Key words
RNA secondary structure/RNA visualization/framework/sequence splitting/sequence comparison分类
信息技术与安全科学引用本文复制引用
石海鹤,万昆,李凤霞,魏美才,牛耕耘..基于模板的rRNA二级结构可视化方法[J].华中科技大学学报（自然科学版）,2025,53(10):49-53,5.基金项目
国家自然科学基金资助项目(62062039,31970447,32370500). （62062039,31970447,32370500）
