井冈山大学学报（自然科学版）2025，Vol.46Issue(6)：56-62,7.DOI:10.3969/j.issn.1674-8085.2025.06.006
抗阻训练改善膝骨关节炎软骨组织损伤的研究
Effects of resistance exercise on improving cartilage tissue injury in rats with knee osteoarthritis
摘要
Abstract
To investigate the effects of resistance exercise on cartilage injury in knee osteoarthritis model rats,and explore its possible mechanism.The SD rats were randomly divided into normal control group(normal group),knee osteoarthritis model group(KOA model group),exercise plus model group(exercise group),10 rats each group.The rat model was prepared by intra-articular injection of sodium glutamate iodoacetic acid solution,14 days of injection later,the model was successfully established and then exercise intervention was carried out.The levels of TNF-α,IL-6 and TLR4/NF-κB pathway-related protein expression were tested,and the knee cartilage of the rats were treated with HE staining and compared using Mankin's score among the three groups,and the wet weight/body weight ratios were calculated at the end of the experiments.The results show that the rats in the model group appeared chondrocyte structure necrosis,with cartilage surface defects,accompanied by disorder and arrangement of each layer cells and clustering phenomenon in the local areas.The above-mentioned pathological phenomena in the exercise group improved significantly.The Mankin's score results showed that the exercise group was significantly lower than the model group(P＜0.05).Compared with the model group,the wet weight/body weight ratios in the exercise group increased significantly(P＜0.01),and were higher than those of the normal group(P＜0.05).Compared with the model group,TLR4,p-NF-κB,p-IκBa protein expressions were significantly decreased in the exercise group(P＜0.05 or P＜0.01).The contents of TNF-α,IL-6 were significantly decreased in the exercise group(P＜0.01).Regular resistance training can increase the muscle mass of quadriceps,and improve the pathological injury of the knee joint cartilage tissue.The mechanism may be related to the weakening of the inflammatory response mediated by the regulation of the expression of key proteins in the TLR4/NF-κB signaling.关键词
抗阻训练/膝骨关节炎/软骨损伤/大鼠Key words
resistance exercise/knee osteoarthritis/cartilage injury/rats分类
生物科学引用本文复制引用
赖林香,朱洪竹..抗阻训练改善膝骨关节炎软骨组织损伤的研究[J].井冈山大学学报（自然科学版）,2025,46(6):56-62,7.基金项目
国家自然科学基金项目(31360255) （31360255）
