寄生虫与医学昆虫学报2025，Vol.32Issue(3)：138-145,8.DOI:10.3969/j.issn.1005-0507.2025.03.002
华支睾吸虫病诊断试验准确性的Meta分析
META-ANALYSIS OF ACCURACY OF DIAGNOSTIC TESTS FOR CLONORCHIASIS
摘要
Abstract
Objective To evaluate the efficacy of the enzyme-linked immunosorbent assay(ELISA),polymerase chain reaction(PCR),and gold chromatographic strip assay(GICA)in diagnosing clonorchiasis through a meta-analysis of diagnostic tests.Methods Relevant databases,including CNKI,the Wan Fang Database,VIP,and PubMed,were searched according to inclusion and exclusion criteria.Literature quality was assessed using RevMan 5.4 and Stata 18,and funnel plots,forest plots,and SROC curves were generated.Results A total of 50 articles met the inclusion criteria.Deeks'funnel plot analysis indicated no significant publication bias among the three methods.The combined effect size analysis revealed that the sensitivity and specificity of ELISA for detecting clonorchiasis were 0.93(0.89-0.95)and 0.94(0.92-0.96),respectively,with an area under the SROC curve of 0.98.For PCR,the sensitivity and specificity were 0.93(0.84-0.97)and 0.92(0.80-0.97),respectively,yielding an area under the SROC curve of 0.97.The sensitivity and specificity of the GICA method for detecting clonorchiasis were 0.91(0.83-0.96)and 0.95(0.87-0.98),respectively,with an area under the SROC curve of 0.97.Conclusions In the diagnosis of clonorchiasis,ELISA,PCR and GICA have high diagnostic value,but their ranges differ from each other.关键词
华支睾吸虫病/Meta分析/华支睾吸虫/诊断试验Key words
Clonorchiasis/Meta-analysis/Clonorchis sinensis/Diagnostic test分类
医药卫生引用本文复制引用
蔡子涵,周育洋,吴琼,周靖,杨毅梅..华支睾吸虫病诊断试验准确性的Meta分析[J].寄生虫与医学昆虫学报,2025,32(3):138-145,8.基金项目
国家自然科学基金项目(No.81460316) （No.81460316）
泗阳医院与江苏大学附属医院联合院内科技计划项目(2024SY005) （2024SY005）
