解放军医学院学报2025，Vol.46Issue(7)：631-637,7.DOI:10.12435/j.issn.2095-5227.25040803
脓毒症相关性脑病临床治疗进展及新策略
Advances and novel strategies in treatment of sepsis-associated encephalopathy
摘要
Abstract
About 50%septic patients develop sepsis-associated encephalopathy(SAE),which may lead to worse prognosis.Therapeutic options with satisfactory specificity are still lacking.The major treatment is based on the management of protopathy,combined with the handling of relevant complications or medical practices,such as delirium,pain,mechanical ventilation weaning,and early movement.Recently,many experiments focusing on the therapeutic pharmacy are performed to target neuroinflammation,protection of blood brain barrier,cellular energy metabolism,necrosis,and neural restoration.Notably,traditional Chinese medicine shows therapeutic effects in SAE trials.As rapid advancement in new medical techniques,the clinical treatment for SAE is expected to be improved in the future.关键词
脓毒症相关性脑病/临床治疗/神经炎症损伤/血脑屏障/脓毒症Key words
sepsis-associated encephalopathy/clinical therapy/neuroinflammation injury/blood brain barrier/sepsis分类
医药卫生引用本文复制引用
刘辉,童森,姚咏明..脓毒症相关性脑病临床治疗进展及新策略[J].解放军医学院学报,2025,46(7):631-637,7.基金项目
国家重点研发计划项目(2022YFA1104600) （2022YFA1104600）
国家自然科学基金重点专项(82241062) （82241062）
北京市自然科学基金项目(7222162) （7222162）
