教育生物学杂志2025，Vol.13Issue(6)：449-454,6.DOI:10.3969/j.issn.2095-4301.2025.06.005
基于身高增长高峰的青少年特发性脊柱侧凸女性患者畸形进展风险预测研究
Prediction of progression risk of scoliosis deformity in female patients with adolescent idiopathic scoliosis based on height growth peak
摘要
Abstract
Objective To explore the relationship between height growth and deformity progression in female patients with adolescent idiopathic scoliosis(AIS),and investigate the predictive value of Risser grading and menarche timing for deformity progression risk.Methods A retrospective analysis was performed on the clinical data of 335 female patients with AIS.Their menarche timing and skeletal maturity index(Risser grading)were recorded.The height growth rate and AIS-related deformity progression rate(expressed as Cobb angle change rate)were compared among patients with different Risser grades.The Kappa coefficient was then used to assess the consistency between deformity progression and growth and development status.Additionally,a linear regression model and the area under the receiver operating characteristic curve(AUC)were used to evaluate the influencing factors of deformity progression and the predictive value of these factors for the progression peak of AIS-related deformity.Results The deformity progression rate of patients with Risser grade 1 was significantly higher than that of those with Risser grades 0,2,and 3(P<0.05).The height growth rate of patients with Risser grade 0 was significantly higher than that of patients with other Risser grades(P<0.01).The Kappa coefficient for the consistency between height growth peak and deformity progression was 0.056(P=0.346).Risser grading was an important factor influencing deformity progression(P<0.05).Menarche timing exhibited a trend of affecting deformity progression(B=-0.023,P=0.069).The combination of Risser grading and menarche timing had a certain predictive value for the risk of AIS-related deformity progression(AUC=0.709,P=0.019).Conclusion In female patients with AIS,the peak of deformity progression occurs later than the peak of height growth.While the Risser grading and menarche timing exhibit poor predictive ability for the height growth peak,they hold certain predictive value for AIS-related deformity progression.关键词
特发性脊柱侧凸/畸形进展/身高/月经初潮时间/青少年/女性Key words
idiopathic scoliosis/deformity progression/height/menarche timing/adolescents/female引用本文复制引用
黄泽凡,周璇,李欣,于虹,靳梦蝶,诸小青,杜青..基于身高增长高峰的青少年特发性脊柱侧凸女性患者畸形进展风险预测研究[J].教育生物学杂志,2025,13(6):449-454,6.基金项目
上海市科学技术委员会"科技创新行动计划"医学创新研究专项项目(22Y21900600) （22Y21900600）
上海申康医院发展中心市级医院诊疗技术推广及优化管理项目(SHDC12023118) （SHDC12023118）
