精准医学杂志2025，Vol.40Issue(5)：377-383,7.DOI:10.13362/j.jpmed.202540105
高通量微流控平台在肿瘤精准诊疗中的应用研究进展
Advances in the application of high-throughput microfluidic platforms in precise diagnosis and treat-ment of tumors
摘要
Abstract
Although the treatment of malignant tumors has entered an era of comprehensive therapy integrating chemo-therapy,targeted therapy,immunotherapy,and other modalities,there is still a significant gap from individualized precise treat-ment.The development of in vivo and in vitro drug sensitivity testing models has promoted the advances in functional precision medicine.Among these models,high-throughput microfluidic platforms offer distinct advantages for in vitro drug sensitivity testing due to their features of high throughput,high sensitivity,high integration,and miniaturization,thereby enabling precise manipula-tion of microliter-volume fluid flow and reactions and simulating the liquid microenvironment of tumor growth.This article reviews the recent research advances in the application of high-throughput microfluidic platforms in the precise diagnosis and treatment of tumors,in order to provide a reference for the individualized treatment of malignant tumors.关键词
高通量筛选分析/药物筛选试验,抗肿瘤/肿瘤微环境/精准医学/述评Key words
High-throughput screening assays/Drug screening assays,antitumor/Tumor microenvironment/Precision medicine/Editorial分类
医药卫生引用本文复制引用
豆立靓,褚佳慧,刘联..高通量微流控平台在肿瘤精准诊疗中的应用研究进展[J].精准医学杂志,2025,40(5):377-383,7.基金项目
国家自然科学基金项目(82173305) （82173305）
山东省自然科学基金项目(ZR2020QH230) （ZR2020QH230）
