精准医学杂志2025，Vol.40Issue(5)：422-428,7.DOI:10.13362/j.jpmed.202540086
炎症性肠病患者疲劳症状发展轨迹及其影响因素
Trajectory of fatigue and related influencing factors in patients with inflammatory bowel disease
摘要
Abstract
Objective To investigate the trajectory of fatigue and related influencing factors in patients with inflammato-ry bowel disease(IBD).Methods A total of 290 IBD patients who attended Department of Gastroenterology,The Affiliated Hospital of Qingdao University,from July 2023 to May 2024 were enrolled as subjects using the method of convenience sampling.Demographic and clinical data were recorded,and the severity of fatigue was assessed at baseline and at 3 and 6 months after atten-ding the hospital.The latent profile analysis(LPA)was used to identify the potential subgroups of fatigue symptom trajectories,and then the patients were divided into different groups.A univariate analysis was used to identify the indicators with statistical sig-nificance in demographic and clinical data across groups,and the above indicators were included in the multivariate logistic regres-sion model to determine the influencing factors for different fatigue symptom trajectories.Results The LPA model identified four distinct fatigue trajectories among IBD patients,i.e.,low fatigue,moderate fatigue with remission,high fatigue with decline,and high fatigue with persistence.The univariate and multivariate logistic regression analyses showed that age,sex,body mass in-dex,presence of anemia,medication(hormone or biological agent),disease activity,sleep quality,and the status of anxiety and depression were influencing factors for fatigue symptom trajectory(P＜0.05).Conclusion There are four distinct fatigue trajec-tories,low fatigue,moderate fatigue with remission,high fatigue with decline,and high fatigue with persistence,in IBD patients within a short term after initial diagnosis.The medical staff can early identify the patients with high fatigue and implement targeted and individualized nursing interventions based on the influencing factors for fatigue symptom trajectories,thereby improving the outcome of fatigue in IBD patients.关键词
炎性肠疾病/疲劳/影响因素分析/纵向研究/潜在类别分析Key words
Inflammatory bowel diseases/Fatigue/Root cause analysis/Longitudinal studies/Latent class analysis分类
医药卫生引用本文复制引用
徐瑛萱,李姗姗,朱婕,邵艳茹,刘雨畅,单信芝..炎症性肠病患者疲劳症状发展轨迹及其影响因素[J].精准医学杂志,2025,40(5):422-428,7.基金项目
青岛市2023年度医药卫生科研指导项目(2023-WJZD061) （2023-WJZD061）
