精准医学杂志2025，Vol.40Issue(5)：429-434,6.DOI:10.13362/j.jpmed.202540115
男性痛风患者发生骨侵蚀的危险因素分析
Risk factors for bone erosion in male patients with gout
摘要
Abstract
Objective To investigate the risk factors associated with bone erosion in male patients with gout.Methods A total of 297 male patients with gout who presented for their initial visit to the Gout Clinical Medical Center of the Affiliated Hos-pital of Qingdao University between January 2020 and December 2021 and underwent musculoskeletal ultrasound examinations were retrospectively enrolled.Based on the presence or absence of bone erosion on musculoskeletal ultrasonography,the patients were classified into a bone-erosion group(n=73)and a non-bone-erosion group(n=224).Clinical,pathological,and ultrasono-graphical parameters were collected and compared between the two groups.A multivariable logistic regression analysis was used to identify risk factors for bone erosion in male gout patients,and a receiver operating characteristic(ROC)curve analysis was per-formed to assess the diagnostic performance of statistically significant factors.Results Significant differences were observed be-tween the two groups in age,gout duration,serum urea nitrogen level,serum creatinine level,estimated glomerular filtration rate(eGFR),family history of gout,the proportion of patients with frequent gout attacks within the past year,the proportion of col-chicine use,and the presence,size,and number of tophi,as well as in the double contour sign and synovial thickening(Z=-4.626--3.361,t=-5.787,x2=4.325-33.515,P＜0.05).The multivariable logistic regression analysis indicated that reduced eGFR,family history of gout,frequent gout attacks within the past year,presence of double contour sign,and increased tophus size were risk factors for bone erosion in male gout patients(Wald x2=4.115-12.263,P＜0.05).The ROC curve analysis showed that the area under the ROC curve of tophus size for predicting bone erosion was 0.744,with an optimal cutoff value of 0.565 cm.Conclusion Reduced eGFR,family history of gout,frequent gout attacks within the past year,presence of double contour sign on ultrasonography,and increased tophus size are potential risk factors for bone erosion in male patients with gout.Among these,to-phus size is a key predictor of bone erosion risk.关键词
痛风/关节炎,痛风性/骨侵蚀/超声检查/危险因素Key words
Gout/Arthritis,gouty/Bone erosion/Ultrasonography/Risk factors分类
临床医学引用本文复制引用
霍飞,艾晓波,任伟,韩琳,李润泽..男性痛风患者发生骨侵蚀的危险因素分析[J].精准医学杂志,2025,40(5):429-434,6.基金项目
山东省自然科学基金项目(ZR2020MH108) （ZR2020MH108）
