精准医学杂志2025，Vol.40Issue(5)：441-445,5.DOI:10.13362/j.jpmed.202540090
孕晚期室内尘螨水平对母婴围生期血液中Th2相关因子水平的影响
Effect of indoor dust mite exposure during late-term pregnancy on Th2-associated cytokine levels in maternal-infant perinatal blood
摘要
Abstract
Objective To investigate the effect of indoor dust mite exposure during late-term pregnancy on Th2-associa-ted cytokine levels in maternal-infant blood.Methods This study enrolled 78 healthy parturients who underwent pregnancy checkups and gave birth to a full-term,singleton fetus via vaginal delivery at our hospital from July 2023 to June 2024;the infants were also included in the study.These parturients and infants were divided into atopic and non-atopic groups based on the constitu-tion of the parturients.Enzyme-linked immunosorbent assay(ELISA)was used to determine the indoor dust mite exposure during late-term pregnancy in these parturients.Based on the results,these parturients and infants were categorized into low-exposure,medium-exposure,and high-exposure groups.The general information,including the sex,age,and body mass index of the partu-rients,as well as the sex,birth weight,and feeding method of the infants,was collected.Maternal blood collected immediately be-fore delivery and neonatal cord blood collected at birth were tested for Th2-associated cytokines(IL-33,IL-13,and IgE),and the results were compared.Follow-up was conducted for the incidence of atopic dermatitis(AD)in the infants in early infancy(within three months).Results In the atopic group,the levels of serum IL-33,IL-13,and IgE in the parturients and serum IL-33 and IL-13 in the infants in the medium-and high-exposure subgroups were significantly higher than those in the low-exposure subgroup(F=3.764-9.454,P＜0.05).In the non-atopic group,the level of serum IgE in the infants in the high-exposure subgroup was sig-nificantly higher than that in the low-exposure subgroup(F=3.327,P＜0.05).In addition,the levels of serum IL-13,IgE in the parturients and serum IL-33 and IgE in the infants in the medium-and high-exposure subgroup were significantly higher in the ato-pic group than in the non-atopic group(t=2.552-8.604,P＜0.05).The incidence of early infantile AD was associated with the le-vels of serum IL-33 and IgE at birth,as well as the atopic constitution of parturients and the levels of maternal prenatal serum IL-33,IL-13,and IgE(x2=11.522,t=2.805-4.490,P＜0.05).Conclusion The increased Th2-associated cytokine levels in mother-infant perinatal serum are associated with increased indoor dust mite exposure in late-term pregnancy.This correlation is particularly pronounced in parturients with atopic constitution.Moreover,the interaction between genetics and the environment in-creases the risk of early AD in infants.关键词
超敏反应/尘螨科/Th2细胞/免疫球蛋白E/白细胞介素-13/白细胞介素-33/皮炎,特应性/婴儿Key words
Hypersensitivity/Pyroglyphidae/Th2 cells/Immunoglobulin E/Interleukin-13/Interleukin-33/Dermatitis,ato-pic/Infant分类
临床医学引用本文复制引用
彭璟,刘彩虹,李超,徐雷,曲政海..孕晚期室内尘螨水平对母婴围生期血液中Th2相关因子水平的影响[J].精准医学杂志,2025,40(5):441-445,5.基金项目
青岛西海新区科技惠民专项项目(2020-59) （2020-59）
