西南医科大学学报2025，Vol.48Issue(6)：561-566,6.DOI:10.3969/j.issn.2096-3351.2025.06.001
血液净化技术在放射性核素内污染治疗中的研究现状与展望
Research Status and Challenges of Blood Purification Techniques in the Treatment of Radionuclide Internal Contamination
摘要
Abstract
The treatment of radionuclide internal contamination mainly relies on pharmacological absorption blocking or excre-tory strategies,but the clinical application of the existing excretory agents is limited due to significant liver and kidney toxicity,suscep-tibility to electrolyte disorders,and other side effects.Therefore,the development of low-toxicity and high-efficiency life-saving treat-ment options is urgent.Blood purification technology has been widely used in the treatment of acute poisoning because it can directly remove toxins and replenish essential trace elements through extracorporeal devices,which can avoid the toxic side effects caused by drug metabolism.Studies have shown that this technique has some potential for removing radionuclides such as cesium and uranium.In this paper,we systematically review the traditional treatments for radionuclide contamination and their limitations,and focus on the mechanism and application prospects of blood purification technology.In addition,the paper also analyzes the current technical bottle-necks,with a view to providing a theoretical basis for optimizing the clinical intervention strategy for radionuclide contamination.关键词
放射性核素/内污染/血液净化技术Key words
Radionuclide/Internal contamination/Blood purification techniques分类
医药卫生引用本文复制引用
王少清,杜印源..血液净化技术在放射性核素内污染治疗中的研究现状与展望[J].西南医科大学学报,2025,48(6):561-566,6.基金项目
中核医疗核医科技创新重点项目(ZHYLZD2021005) （ZHYLZD2021005）
四川省中医药管理局中医药科研专项项目(2024MS155) （2024MS155）
成都医学院研究生创新研究基金项目(YCX2024-01-36) （YCX2024-01-36）
