西南医科大学学报2025，Vol.48Issue(6)：611-616,6.DOI:10.3969/j.issn.2096-3351.2025.06.009
慢性阻塞性肺疾病急性加重期患者合并慢性肺源性心脏病的危险因素与临床特征分析
Risk Factors and Clinical Characteristics of Chronic Cor Pulmonale in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective This study aimed to analyze the independent risk factors and clinical characteristics of CCP in patients with AECOPD.Method In this cross-sectional study,294 AECOPD patients were divided into two groups:the AECOPD group(n=202)and the AECOPD combined with CCP group(n=92).Demographics,underlying diseases,pulmonary function,and laboratory tests within 24 hours of being hospitalized were collected.Univariate analysis was performed.Binary logistic regression analysis was used to explore the independent risk factors and clinical characteristics for the combination of CCP in AECOPD patients.Nomogram and its related curves were used to analyze the results of the binary logistic regression analysis.Results Univariate analysis showed that age,mechanical ventilation,CAP,GOLD stages,PH,PaCO2,lymphocytes,eosinophils,platelets,red blood cells,Hb,and AST have significant differences(P<0.05).The nomogram model constructed based on binary logistic regression(including PaCO2,Hb,GOLD classification,and age)demonstrated good predictive performance for AECOPD patients with CCP(AUC=0.783).Cali-bration curves and DCA analysis(risk threshold of 0.1 to 0.7)confirmed its high clinical predictive value.Conclusions High PaCO2,Hb,and GOLD classification,as well as advanced age,were independent clinical characteristics of AECOPD patients with CCP.AECOPD patients with CCP had more severe conditions and poorer prognoses,requiring early prevention and intervention.关键词
慢性阻塞性肺疾病急性加重期/慢性肺源性心脏病/危险因素/临床特征Key words
Acute exacerbation of chronic obstructive pulmonary disease(AECOPD)/Chronic cor pulmonale(CCP)/Risk factors/Clinical characteristics分类
医药卫生引用本文复制引用
王海鑫,李娅,陈自强,王小川,王汉超,谢丽,朱涛,罗晓斌..慢性阻塞性肺疾病急性加重期患者合并慢性肺源性心脏病的危险因素与临床特征分析[J].西南医科大学学报,2025,48(6):611-616,6.基金项目
四川省自然科学基金面上项目(2025NSFSC0656) （2025NSFSC0656）
中华国际医学交流基金会呼吸疾病青年实用研究项目(Z-2017-24-2301) （Z-2017-24-2301）
四川省卫生健康委员会科技项目(23LCYJ008) （23LCYJ008）
