南京中医药大学学报2025，Vol.41Issue(11)：1441-1451,11.DOI:10.14148/j.issn.1672-0482.2025.1441
人源组织类器官:中医药抗病毒研究的新前沿
Human tissue Organoids:A New Frontier of Antiviral Research in Traditional Chinese Medicine
摘要
Abstract
Viruses,with high adaptability and immune evasion capabilities,are responsible for a wide spectrum of diseases from lo-calized infections to global pandemics,continuously posing threats to global public health.In recent years,traditional Chinese medi-cine(TCM)has demonstrated significant potential in antiviral therapy.With its multi-component,multi-target synergistic mechanism,TCM offers unique advantages in the intervention of viral diseases.However,progress in elucidating the active antiviral constituents of TCM and identifying their precise molecular targets remains limited,primarily due to the lack of humanized models that can faithfully recapitulate the natural course of viral infection.The emergence of organoid technology has introduced new opportunities for antiviral research in TCM.Human organoids,which recapitulate the three-dimensional architecture and physiological functions of human tis-sues,provide an advanced platform for modeling host-virus interactions in a human-relevant context.This article highlights the latest advances in applications of human tissue organoids,including lung,liver,and brain organoids,in the study of respiratory viruses(SARS-CoV-2,influenza virus,respiratory syncytial virus),hepatitis viruses(HBV,HCV,HEV),and neurotropic viruses(ZIKV,pri-ons,HCMV);illustrates how organoid models have been leveraged to evaluate both the efficacy and safety of TCM-based antiviral inter-ventions.Although human tissue organoids still face technical challenges in insufficient vascularization and incomplete immune micro-environment,they represent a powerful tool for dissecting the mechanism of TCM antiviral action and for guiding the development of personalized antiviral strategies.Looking ahead,human tissue organoid technology is expected to become key enabling platform for pro-moting the clinical transformation of TCM in the field of antiviral medicine.关键词
中医药/病毒感染/肺类器官/肝脏类器官/脑类器官Key words
traditional Chinese medicine/viral infection/lung organoid/liver organoid/brain organoid分类
医药卫生引用本文复制引用
高玲,曲长澍,徐智雯,刘世博,涂若诗,聂运中..人源组织类器官:中医药抗病毒研究的新前沿[J].南京中医药大学学报,2025,41(11):1441-1451,11.基金项目
国家重点研发计划(2023YFC2308200) （2023YFC2308200）
国家自然科学基金面上项目(82302396) （82302396）
