南京中医药大学学报2025，Vol.41Issue(11)：1452-1463,12.DOI:10.14148/j.issn.1672-0482.2025.1452
鲜药来源纳米囊泡在病毒感染性疾病治疗中的应用
Application of Fresh Herb-Derived Nanovesicles in the Treatment of Virus-Induced Infectious Diseases
摘要
Abstract
Viruses,as important biological agents influencing human health and social development,have played a key role in the spread of epidemics and the evolution of diseases since ancient times.Upon infecting hosts,viruses often trigger a series of com-plex responses,including innate and adaptive immunity,inflammatory responses and pathological damage.Despite advances in mod-ern antiviral drugs development,chemical drugs typically rely on a single molecular target within the viral life cycle,making them highly susceptible to the emergence of drug resistance and the induction of systemic toxic side effects.In contrast,traditional Chi-nese medicines(TCMs),posing the distinctive advantage of multi-component,multi-target,and multi-pathway,have exerted a pivotal role in viral prevention and viral treatment.In recent years,fresh herbs have gained increasing attention for their ability to preserve intact bioactive components.Fresh herb-derived nanovesicles possess excellent biocompatibility,targeting and cross-species regula-tory capabilities.These fresh herb-derived nanovesicles can effectively encapsulate and deliver a variety of antiviral components,demonstrating significant potential in antiviral immunomodulation,inflammation control and viral-induced pathologies.This review systematically sorts out the mechanisms of viral infection,and summarizes the advantages of fresh herbs,and the application pros-pects of fresh herb-derived nanovesicles in antiviral therapy.Furthermore,it focuses on summarizing the research progress of fresh herb-derived nanovesicles in the field of antiviral therapy,with the aim of providing insights and references for the development of fresh herb-derived nanovesicles-based antiviral strategies,as well as offering novel approaches and perspectives for the clinical treat-ment of viral diseases.关键词
中药/鲜药/鲜药来源纳米囊泡/抗病毒Key words
traditional Chinese medicine/fresh herb/fresh herb-derived nanovesicles/antiviral infectious disease分类
医药卫生引用本文复制引用
刘祺祎,庄舒雅,付冀川,曹鹏,王浩然..鲜药来源纳米囊泡在病毒感染性疾病治疗中的应用[J].南京中医药大学学报,2025,41(11):1452-1463,12.基金项目
国家重点研发计划(2023YFC2308200) （2023YFC2308200）
国家杰出青年科学基金项目(82125037) （82125037）
