南京中医药大学学报2025，Vol.41Issue(11)：1503-1511,9.DOI:10.14148/j.issn.1672-0482.2025.1503
中药调控呼吸道合胞病毒感染相关信号通路的研究进展
Research Progress on the Regulation of Respiratory Syncytial Virus Infection-Related Signaling Pathways by Chinese Medicine
摘要
Abstract
Respiratory syncytial virus(RSV)infection is a major respiratory disease threatening the health of infants and immuno-compromised populations worldwide,with no specific therapeutic drugs available.Traditional Chinese medicine(TCM)has shown unique advantages of multi-target and multi-pathway in the prevention and treatment of RSV infection,and its mechanism is closely re-lated to the regulation of cellular signaling pathways.This article systematically reviews the research progress of TCM including mono-mer components and compound prescriptions in intervening RSV infection through nuclear factor-κB(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),mitogen-activated protein kinase(MAPK),nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1)and other signaling pathways.Current re-search still has problems such as insufficient analysis of pathway synergy mechanisms,unclear material basis of compounds,and single technical means.Future studies should focus on cross-talk of multiple pathways,identification of active component groups of TCM,and research on"syndrome-type-pathway"association,combined with cutting-edge technologies such as network pharmacology and or-ganoid models,so as to provide a scientific basis for the mechanism and clinical transformation of TCM against RSV infection.关键词
中药/呼吸道合胞病毒/信号通路/研究进展Key words
Chinese medicines/respiratory syncytial virus/signal pathway/research progress引用本文复制引用
姜裔婷,何峰,冯淼,李森,曹丁丁,姚海兰..中药调控呼吸道合胞病毒感染相关信号通路的研究进展[J].南京中医药大学学报,2025,41(11):1503-1511,9.基金项目
国家重点研发计划(2023YFC2308200) （2023YFC2308200）
