南京中医药大学学报2025，Vol.41Issue(11)：1512-1520,9.DOI:10.14148/j.issn.1672-0482.2025.1512
中药对CVB3诱导病毒性心肌炎的多靶点干预机制及临床应用
Multi-Target Intervention Mechanism and Clinical Application of Traditional Chinese Medicine in CVB3-Induced Viral Myocarditis
摘要
Abstract
Viral myocarditis(VMC)is a type of myocarditis caused by Coxsackievirus B3(CVB3)infection.Its pathogenesis is complex that includes direct viral action,host immune and inflammatory response,myocardial structure and function remodeling.The therapeutic effect of single target drugs is limited,while traditional Chinese medicine not only has antiviral effects,but also demon-strates systematic advantages in intervening in VMC due to its"multi-component,multi-target,and multi-pathway"characteristics.This article reviews the pathogenic mechanisms of CVB3-induced VMC,clarifies the interaction between CVB3 and host cells,and ex-plores the intervention mechanisms and developments of traditional Chinese medicine interventions for CVB3-induced VMC.At the same time,the prospects of traditional Chinese medicine treatment for CVB3-induced VMC in this study suggest that future research should strengthen the analysis of multi-target synergistic mechanisms based on traditional Chinese medicine formulas,combine artifi-cial intelligence,genomics,and gene editing technologies to predict drug-target interaction networks,establish standardized and per-sonalized system for integrated traditional Chinese and Western medicine treatment plans,and provide more effective strategies for the prevention and treatment of VMC.关键词
柯萨奇病毒B组3型/病毒性心肌炎/中药/致病机制/多靶点干预Key words
Coxsackievirus B3/viral myocarditis/traditional Chinese medicine/pathogenic mechanism/multi-target intervention分类
医药卫生引用本文复制引用
刘宓,章立峰,杜海军,梅国勇,夏志强,韩俊..中药对CVB3诱导病毒性心肌炎的多靶点干预机制及临床应用[J].南京中医药大学学报,2025,41(11):1512-1520,9.基金项目
国家重点研发计划(2023YFC2308200) （2023YFC2308200）
国家病原微生物资源库项目(NPRC-32) （NPRC-32）
