南京中医药大学学报2025，Vol.41Issue(11)：1531-1540,10.DOI:10.14148/j.issn.1672-0482.2025.1531
基于糖基化模式探讨中药干预糖缀合物抗呼吸道病毒感染的潜力
Exploring the Potential of Intervening Glycoconjugate in Traditional Chinese Medicine against Respira-tory Viral Infections Based on Glycosylation Patterns
摘要
Abstract
The high pathogenicity and mortality of respiratory viral infections pose a significant clinical burden.Due to the high de-gree of variability of viral proteins,some current targeted drugs are highly susceptible to drug resistance,and there is an urgent need for the development of effective therapeutic strategies.Glycoconjugates are widely distributed in hosts and viruses,and participate in host-virus interactions,viral replication,innate and adaptive immunity,etc.Aberrant glycosylation is involved in the pathogenesis of a vari-ety of diseases,and anti-respiratory viral strategies targeting glycosylation have the advantages of high specificity,low drug resistance,and broad-spectrum.In recent years,traditional Chinese medicines(TCMs)have shown unique potential in intervening in glycosylation-related antiviral fields due to their multi-target regulatory properties.The aim of this paper is to focus on the biological functions of glycosylation modifications,the research progress of virus infection and potential TCM monomers targeting glycosylation,which not only reveals the scientific connotation of TCM regulation of glycosylation,but also provides a natural molecular library for the development of novel antiviral strategies based on glycosylation intervention.In the future,it is necessary to further combine the tech-niques of glycomics and structural biology to elucidate the precise mechanism of spatial and temporal dynamics of TCM monomers in regulating glycosylation,and to promote the modernization of TCM.关键词
呼吸道病毒感染/糖缀合物/糖基化修饰/中药Key words
respiratory viral infection/glycoconjugate/glycosylation modification/traditional Chinese medicine分类
医药卫生引用本文复制引用
康玥,张钊玮,曹鹏,纪建建..基于糖基化模式探讨中药干预糖缀合物抗呼吸道病毒感染的潜力[J].南京中医药大学学报,2025,41(11):1531-1540,10.基金项目
国家重点研发计划(2023YFC2308200) （2023YFC2308200）
国家自然科学基金青年科学基金项目(82304497) （82304497）
