器官移植2025，Vol.16Issue(6)：859-865,7.DOI:10.12464/j.issn.1674-7445.2025212
纳米技术在肾移植中的应用进展
Application advances of nanotechnology in kidney transplantation
摘要
Abstract
Kidney transplantation is the preferred treatment option for end-stage renal disease.Although early prognosis has significantly improved,the long-term survival rate has not increased substantially.There are still significant challenges in addressing organ shortage,maintaining the quality of donor kidneys,and preventing and managing postoperative complications.Nanotechnology,with its unique physicochemical and biological advantages,shows broad application prospects in maintaining graft function while achieving precise immune regulation and complication management,providing new opportunities for the diagnosis,treatment and management of kidney transplantation.The applications of nanotechnology include donor kidney protection,human leukocyte antigen typing of donors and recipients,early diagnosis of postoperative complications such as rejection and infection,and targeted treatment of ischemia-reperfusion injury and rejection.This article systematically reviews and discusses the relevant research progress,evaluates the advantages and potential risks of nanotechnology in kidney transplantation,and explores the challenges and development directions for its clinical translation,aiming to provide references for promoting the precise and individualized management of kidney transplantation.关键词
纳米技术/肾移植/早期诊断/缺血-再灌注损伤/排斥反应/终末期肾病/细胞外囊泡/人类白细胞抗原Key words
Nanotechnology/Kidney transplantation/Early diagnosis/Ischemia-reperfusion injury/Rejection/End-stage renal disease/Extracellular vesicle/Human leukocyte antigen分类
医药卫生引用本文复制引用
张金华,孙其鹏..纳米技术在肾移植中的应用进展[J].器官移植,2025,16(6):859-865,7.基金项目
广东省基础与应用基础研究基金项目(2021A1515011379) （2021A1515011379）
暨南大学附属广东省第二人民医院人才引进研究启动基金(2025-DW-KZ-031-01) （2025-DW-KZ-031-01）
