器官移植2025，Vol.16Issue(6)：874-880,7.DOI:10.12464/j.issn.1674-7445.2025195
异种肺移植临床前研究进展及单中心技术经验
Progress in preclinical studies of xenogeneic lung transplantation and single-center technical experience
摘要
Abstract
Lung transplantation is the ultimate therapeutic option for end-stage pulmonary diseases such as interstitial pneumonia,chronic obstructive pulmonary disease and pneumoconiosis.Currently,the shortage of allogeneic lung donors significantly limits the opportunity for end-stage lung disease patients to receive lung transplantation.In recent years,with the rapid development of biomedical engineering technologies,especially the major breakthroughs in genetic modification and cloning,xenogeneic lung transplantation has shown important potential for clinical translation.Among them,genetically modified pigs have become the most promising xenogeneic lung source due to the close similarity of organ size and physiological characteristics to humans,and the ability to perform targeted gene knockouts(such as α-Gal antigen knockout)to reduce the occurrence of hyperacute rejection.This article focuses on the research progress of porcine xenogeneic lung transplantation,systematically reviews the latest achievements and challenges in animal experiments and human trials,and introduces the technical experience accumulated by Shenzhen Third People's Hospital in the porcine-to-monkey xenogeneic lung transplantation model,in the hope of providing practical references for future research in this field.关键词
异种肺移植/器官短缺/基因修饰猪/离体肺灌注/免疫抑制/病原体/猪内源性逆转录病毒/移植物存活Key words
Xenogeneic lung transplantation/Organ shortage/Genetically modified pig/Ex vivo lung perfusion/Immunosuppression/Pathogen/Porcine endogenous retrovirus/Graft survival分类
医药卫生引用本文复制引用
陶筱婷,魏红江,乔坤,宁新忠,刘永,张桂梅,肖贺,林世雨,周孜孜,魏太云,胡春晓..异种肺移植临床前研究进展及单中心技术经验[J].器官移植,2025,16(6):874-880,7.基金项目
国家科技重大专项科技创新项目(2023ZD0501905) （2023ZD0501905）
深圳市"医疗卫生三名工程"(SZSM202311034) （SZSM202311034）
深圳市"高水平医院建设专项经费"(24275G1007、XKJS-2025023) （24275G1007、XKJS-2025023）
