器官移植2025，Vol.16Issue(6)：962-969,8.DOI:10.12464/j.issn.1674-7445.2025199
细胞外组蛋白在异种移植中的作用研究进展
Research progress on the role of extracellular histones in xenotransplantation
摘要
Abstract
Organ transplantation faces the challenge of a shortage of donors.Although xenotransplantation holds great potential,it is limited by rejection.Extracellular histones,as key members of damage-associated molecular patterns,have been proven in recent years to play a crucial role in transplant rejection by activating innate immunity,regulating the coagulation-inflammation network,and modulating adaptive immune responses.However,the specific functions and key mechanisms remain to be clarified.Therefore,this article reviews the structural characteristics of histones,their release pathways,the biological functions of extracellular histones,and their potential roles in xenotransplantation.It summarizes the latest research progress of extracellular histones in xenotransplantation,analyzes the shortcomings of existing research and the direction for future research,with the expectation of providing references for the application of extracellular histones in xenogeneic kidney transplantation.关键词
细胞外组蛋白/异种移植/器官移植/排斥反应/免疫细胞/损伤相关分子模式/中性粒细胞胞外诱捕网/NOD样受体蛋白3Key words
Extracellular histone/Xenotransplantation/Organ transplantation/Rejection/Immune cell/Damage-associated molecular pattern/Neutrophil extracellular trap/NOD-like receptor protein 3分类
医药卫生引用本文复制引用
王崑,张宇,陈羽翔,马晓杰,李涛,蒋鸿涛..细胞外组蛋白在异种移植中的作用研究进展[J].器官移植,2025,16(6):962-969,8.基金项目
国家重点研发计划(2024YFC3406800) （2024YFC3406800）
国家自然科学基金(82460153、82400891) （82460153、82400891）
海南省卫生健康科技创新联合项目(WSJK2025MS163) （WSJK2025MS163）
海南省优秀人才团队建设任务 （）
海南省临床医学中心建设项目 （）
海南省级博士研究生创新课题(Qhyb2023-179) （Qhyb2023-179）
