四川中医2025，Vol.43Issue(11)：84-93,10.DOI:10.26946/j.cnki.1000-3649.sczy.2505080008
虾蟹类发物与恶性肿瘤的孟德尔随机化研究
Mendelian randomization study on the relationship between"stimulating food"as shrimp and crab and malignant tumors
摘要
Abstract
Objective To investigate the correlation between stimulating food as shrimp and crab and the risk of malignant tumor by TSMR analysis method.Methods In the OpenGWAS database,the single nucleotide polymorphisms(SNP)that are strongly associated with the exposure factor of stimulating food as shrimp and crab were selected as instrumental variables.GWAS statistics for six cancers(thyroid cancer,gastric cancer,liver cancer,lung cancer,colorectal cancer,breast cancer)from the FinnGen and OpenGWAS databases were used as outcome variables.Inverse-variance weighting(IVW)was used as the primary analysis method,followed by heterogeneity test,pleiotropic analysis,and sensitivity analysis.Results This study included 19 independent SNPs associated with the intake of shrimp and crab as instrumental variables.The IVW analysis showed no statistically significant causal effect between shrimp and crab intake and six types of cancer(P>0.05).The study results were not affected by multiplicity,and sensitivity analysis confirmed the reliability of the results.Conclusion This MR study shows that stimulating food as shrimp and crab has no obvious correlation with malignant tumor.However,due to the lack of data and accuracy,further in-depth research should be carried out to provide a solid evidence-based basis for enriching and improving the theory of TCM.关键词
虾蟹类发物/恶性肿瘤/孟德尔随机化Key words
Stimulating food as shrimp and crab/Malignant tumor/Mendelian randomization study分类
中医学引用本文复制引用
岑怡,殷晓聆,高丹丹,石齐,高嵩,王亚乐,侯风刚..虾蟹类发物与恶性肿瘤的孟德尔随机化研究[J].四川中医,2025,43(11):84-93,10.基金项目
国家自然科学基金项目(82174188,81904005) （82174188,81904005）
全国中医临床优秀人才项目(R221127N) （R221127N）
上海市浦东新区中医薄弱学科建设项目(PDZY-2020-0406). （PDZY-2020-0406）
