世界科学技术-中医药现代化2025，Vol.27Issue(11)：3108-3118,11.DOI:10.11842/wst.20250720008
心气虚证冠心病患者的认知功能和心脑电耦合的关系研究
Relationship Between Cognitive Function and Cardio-Electroencephalographic Coupling in Coronary Heart Disease Patients with Heart-Qi Deficiency Pattern
摘要
Abstract
Objective To explore their inter-relationship,cognitive performance and cardio-electroencephalographic coupling in coronary heart disease(CHD)patients with heart-qi deficiency pattern were characterized.Methods Thirty CHD patients who met the diagnostic criteria for heart-qi deficiency were enrolled.Thirty healthy volunteers without heart-qi deficiency or CHD served as controls.Cognitive function was assessed with the repeatable battery for the assessment of neuropsychological status(RBANS).Simultaneous resting-state electrocardiogram and electroencephalogram were recorded,and the strength of heart-brain coupling was quantified by calculating the maximal information coefficient(MIC)between heart-rate variability(HRV)and EEG signals.Results Compared with controls,heart-qi deficiency CHD patients showed lower RBANS total scores and reduced performance in immediate memory,visuospatial/constructional ability,and attention.Significant between-group differences in HRV-EEG MIC values were observed at several channels(P<0.05).In patients,the MIC values for HRV-Beta(channel FC1)and HRV-Delta(channel F2)were positively correlated with RBANS total score(P<0.05).Conclusion CHD patients with heart-qi deficiency exhibit impaired cognition and altered cardio-electroencephalographic coupling.These findings suggest that heart-brain interactions may contribute to the pathophysiological mechanisms underlying cognitive decline in this population.关键词
冠心病/认知功能/最大信息系数/心脑耦合Key words
Coronary heart disease/Cognitive function/Maximal information coefficient/Heart-brain coupling分类
医药卫生引用本文复制引用
霍碧岫,王斌,张云河,冯思同,宁艳哲,贾竑晓..心气虚证冠心病患者的认知功能和心脑电耦合的关系研究[J].世界科学技术-中医药现代化,2025,27(11):3108-3118,11.基金项目
国家自然科学基金委员会面上项目(82474429):《内经》火行人和水行人自上而下和自下而上注意加工差异的神经机制研究,负责人:贾竑晓. （82474429）
