世界科学技术-中医药现代化2025，Vol.27Issue(11)：3126-3132,7.DOI:10.11842/wst.20250720005
亚健康脾气虚证患者大尺度脑网络内及网络间静息态功能连接异常研究
Abnormalities in Large-Scale Brain Network Resting-State Functional Connectivity in Sub-Health Patients with Spleen Qi Deficiency Syndrome
摘要
Abstract
Objective To explore the neuroimaging mechanisms of sub-health patients with spleen qi deficiency syndrome based on large-scale brain network resting-state functional connectivity.Methods Thirty-seven sub-health patients with spleen qi deficiency syndrome and 37 healthy controls were enrolled.All subjects underwent resting-state functional magnetic resonance imaging(fMRI)scans.Functional connectivity within and between large-scale brain networks was analyzed and compared between the two groups.The correlation between abnormal changes in brain network functional connectivity in the sub-health spleen qi deficiency syndrome group and spleen qi deficiency syndrome scores was also analyzed.Results Compared with the healthy control group,the sub-health spleen deficiency syndrome group showed significantly reduced functional connectivity within and between brain networks,including the visual network,sensorimotor network,dorsal attention network,frontoparietal network,and default mode network(P<0.05,NBS correction,5000 permutations).Among these,the functional connectivity between the sensorimotor network and the frontoparietal network(r=-0.357,P=0.030)and between the dorsal attention network and the frontoparietal network(r=-0.360,P=0.029)showed a significant negative correlation with the spleen qi deficiency syndrome score.Conclusion Abnormal changes in functional connectivity within and between large-scale brain networks in sub-health patients with spleen deficiency syndrome provide further neuroimaging evidence for the cognitive psychological connotation of the"spleen in storing idea"theory.关键词
脾气虚证/亚健康/静息态/大尺度脑网络/功能连接Key words
Spleen qi deficiency syndrome/Sub-health/Resting-state/Large-scale brain networks/Functional connectivity分类
医药卫生引用本文复制引用
冯思同,吴子遥,宁艳哲,贾竑晓..亚健康脾气虚证患者大尺度脑网络内及网络间静息态功能连接异常研究[J].世界科学技术-中医药现代化,2025,27(11):3126-3132,7.基金项目
国家自然科学基金委员会面上项目(82174311):基于"脾藏意"的脾气虚证所致工作记忆异常的神经机制研究,负责人:贾竑晓 （82174311）
深圳市'医疗卫生三名工程'项目资助(SZZYSM202411001),首都医科大学附属北京安定医院贾竑晓教授中医睡眠情志病诊疗团队,负责人:贾竑晓. （SZZYSM202411001）
