世界科学技术-中医药现代化2025，Vol.27Issue(11)：3133-3140,8.DOI:10.11842/wst.20250720002
基于独立成分分析脾气虚证与肾气虚证亚健康患者认知功能损伤的静息态fMRI脑影像学表征
Resting-State fMRI Biomarkers of Cognitive Dysfunction in Sub-health Patients with Spleen Qi Deficiency Syndrome and Kidney Qi Deficiency Syndrome Based on Independent Component Analysis
摘要
Abstract
Objective To explore the neuroimaging mechanisms of cognitive impairment in sub-health patients with spleen qi deficiency syndrome and kidney qi deficiency syndrome using independent component analysis.Methods 40 sub-health patients with spleen qi deficiency syndrome and 40 kidney qi deficiency syndrome were recruited.All subjects underwent repeated neuropsychological testing and resting-state functional magnetic resonance imaging(fMRI)scans.Independent component analysis was used to compare functional connectivity differences between the two groups of subjects in the default mode network(DMN),frontoparietal network(FPN),dorsal attention network(DAN),and executive control network(ECN).The relationship between the differences in functional connectivity and cognitive function in the two groups of patients was also analyzed.Results In sub-health patients with spleen deficiency syndrome,the DMN included six brain regions,including the bilateral superior parietal lobule,left inferior occipital gyrus,and left lingual gyrus.The FPN included four brain regions,including the left superior parietal gyrus and the left caudate nucleus,the DAN included two brain regions,including the right superior temporal gyrus and the left medial frontal gyrus,and the ECN included the left central parietal lobule.The functional connectivity between the spleen qi deficiency syndrome symptom score and the left middle temporal gyrus and right superior temporal gyrus showed a significant positive correlation(r=0.371,P=0.028).In sub-health kidney qi deficiency syndrome patients,the DMN included six brain regions,including the left superior temporal gyrus,left precuneus,and right angular gyrus,the FPN included three brain regions,including the right middle temporal gyrus and right superior temporal gyrus,the DAN included four brain regions,including the right wedge lobe and the left medial frontal superior gyrus,and the ECN included the left central paracentral lobule and the right central posterior gyrus.Among these,the functional connectivity between the left wedge lobe and the left frontal middle gyrus showed a significant positive correlation with the syndrome score of kidney qi deficiency(r=0.404,P=0.016).Conclusion Sub-health patients with spleen qi deficiency syndrome and kidney qi deficiency syndrome exhibit different neuroimaging bases for cognitive impairment,providing neuroimaging evidence to elucidate the differences in the cognitive psychological connotation of the theories of"spleen in storing idea"and"kidney storing will".关键词
脾气虚证/肾气虚证/亚健康/静息态/独立成分分析Key words
Spleen qi deficiency syndrome/Kidney qi deficiency syndrome/Sub-health/Resting state/Independent component analysis分类
医药卫生引用本文复制引用
冯思同,吴子遥,董麟瑞,宁艳哲,贾竑晓..基于独立成分分析脾气虚证与肾气虚证亚健康患者认知功能损伤的静息态fMRI脑影像学表征[J].世界科学技术-中医药现代化,2025,27(11):3133-3140,8.基金项目
国家自然科学基金委员会面上项目(82174311):基于"脾藏意"的脾气虚证所致工作记忆异常的神经机制研究,负责人:贾竑晓 （82174311）
国家自然科学基金委员会面上项目(81873398):基于"肾藏志"理论的肾虚证所致注意网络异常及神经机制研究,负责人:贾竑晓 （81873398）
深圳市'医疗卫生三名工程'项目资助(SZZYSM202411001):首都医科大学附属北京安定医院贾竑晓教授中医睡眠情志病诊疗团队,负责人:贾竑晓. （SZZYSM202411001）
