世界科学技术-中医药现代化2025，Vol.27Issue(11)：3141-3147,7.DOI:10.11842/wst.20250720001
基于症候脑区映射探究慢性疲劳综合征脾虚和肝郁的脑机制研究
Exploring the Brain Mechanisms of Spleen Deficiency and Liver Stagnation in Chronic Fatigue Syndrome Based on Symptom Brain Mapping
摘要
Abstract
Objective To investigate their potential differences in brain functional characteristics from a neuroimaging perspective,functional magnetic resonance imaging(fMRI)was employed.Methods Twenty chronic fatigue syndrome(CFS)patients were recruited and underwent assessments of traditional Chinese medicine(TCM)syndrome patterns,fatigue severity scores,and resting-state fMRI scans.First,correlation analysis was performed between fatigue scores and TCM symptom scores.Symptom clusters significantly associated with fatigue were categorized into spleen deficiency and liver stagnation groups.Principal component analysis(PCA)was then applied to identify the dominant symptom components for each group.These components were subsequently mapped onto whole-brain functional activity to compare the neural signatures between the two syndromes.Finally,the brain functional profiles of spleen deficiency and liver stagnation were compared with publicly available neurotransmitter receptor maps to explore their distinct neurochemical substrates.Results Symptoms correlated with fatigue severity included exhaustion,dizziness,chest tightness,bitter taste in the mouth,epigastric fullness,poor appetite,irritability,lumbar soreness,sallow complexion,dry eyes,and five-center-heat.The brain mapping results revealed that spleen deficiency-related symptoms(poor appetite,sallow complexion,reduced food intake,dizziness)were primarily associated with the left thalamus and left parahippocampal gyrus.Liver stagnation-related symptoms(dry eyes,chest tightness,irritability,bitter taste)were linked to the left parahippocampal gyrus and right middle occipital gyrus(lingual region).The functional brain spectrum of the two syndromes showed significant negative correlations.Moreover,the spleen deficiency spectrum was closely associated with vesicular acetylcholine transporter(VAChT)receptor density.The liver stagnation spectrum correlated with D2 dopamine receptor density.Both spectrums were significantly related to glucose metabolic density but exhibited opposing directional trends.Conclusion CFS patients with spleen deficiency and liver stagnation demonstrate distinct central functional activities and neurochemical substrates,along with opposing brain activity patterns.Clinically,differentiating between these two syndrome patterns is critical for applying targeted TCM interventions.关键词
症候脑区映射/脾虚/肝郁/fMRI/神经递质/代谢Key words
Symptom brain mapping/Spleen deficiency/Liver stagnation/fMRI/Neurotransmitters/Metabolism分类
医药卫生引用本文复制引用
吴康,李匡时,宁艳哲,冯思同,贾竑晓..基于症候脑区映射探究慢性疲劳综合征脾虚和肝郁的脑机制研究[J].世界科学技术-中医药现代化,2025,27(11):3141-3147,7.基金项目
国家自然科学基金委员会面上项目(82174311):基于"脾藏意"的脾气虚证所致工作记忆异常的神经机制研究,负责人:贾竑晓 （82174311）
国家自然科学基金委员会青年科学基金项目(82004437):基于fMRI/sEMG/ANT技术探讨太极拳改善慢性疲劳综合征效应机制的多尺度脑网络研究,负责人:李匡时. （82004437）
