世界科学技术-中医药现代化2025，Vol.27Issue(11)：3148-3156,9.DOI:10.11842/wst.20250720006
慢性疲劳综合征脾虚证患者的工作记忆损害
Work Memory Impairment in Patients with Chronic Fatigue Syndrome and Spleen Deficiency
摘要
Abstract
Objective To characterize working memory performance in patients with chronic fatigue syndrome(CFS)and spleen-deficiency syndrome and to examine its associations with clinical symptoms by Sternberg working memory task(SWMT).Methods 31 CFS patients meeting both CDC-1994 criteria and consensus criteria for spleen-deficiency pattern were recruited from outpatient clinics and universities from September 2022 and June 2025.31 healthy controls were also recruited based on age,sex,and education.All subjects completed the SWMT.Group differences were analyzed.Within the CFS cohort,reaction time(RT)was correlated with scores on the checklist individual strength(CIS),36-item short-form health survey(sf-36),and fatigue scale-14(FS-14).Mediation was examined.Results RT lengthened with increasing memory load in both groups.CFS patients displayed slower RTs than controls in the baseline and 6-digit set(P<0.05).The 3-digit RT difference,though not significant(P>0.05),yielded a medium effect size(r=0.36).Accuracy did not differ between two groups.Among CFS patients,3-digit RT correlated positively with CIS total and the 4 sub-scale scores.6-digit RT correlated with the SF-36 health-transition dimension(r=0.396,P=0.027).CIS and FS-14 scores directly impaired SF-36 social functioning without working-memory mediating.Conclusion CFS patients with spleen-deficiency exhibit slowed processing speed rather than capacity loss.The close link between working-memory slowing and fatigue suggests a distinct neural basis.These results support the traditional concept"the spleen stores Yi"and integrate TCM pattern differentiation with modern cognitive neuroscience in CFS.关键词
慢性疲劳综合征/脾虚证/工作记忆/脾藏意Key words
Chronic fatigue syndrome/Spleen deficiency syndrome/Working memory/Spleen storing Yi分类
医药卫生引用本文复制引用
周天,张云河,吴子遥,冯思同,宁艳哲,贾竑晓..慢性疲劳综合征脾虚证患者的工作记忆损害[J].世界科学技术-中医药现代化,2025,27(11):3148-3156,9.基金项目
国家自然科学基金委员会面上项目(82174311):基于"脾藏意"的脾气虚证所致工作记忆异常的神经机制研究,负责人:贾竑晓. （82174311）
