世界科学技术-中医药现代化2025，Vol.27Issue(11)：3183-3195,13.DOI:10.11842/wst.20250113008
中药单体治疗骨关节炎中软骨细胞凋亡相关信号通路的研究进展
Research Progress on Signaling Pathways Related to Chondrocyte Apoptosis in the Treatment of Osteoarthritis with Traditional Chinese Medicine Monomers
摘要
Abstract
Osteoarthritis is a chronic degenerative joint disorder that adversely affects the quality of life of patients.Its pathological characteristics mainly involve the degeneration,destruction,and functional loss of articular cartilage.As one of the most crucial structures in the joint,articular cartilage is an avascular tissue composed of extracellular matrix synthesized by sparsely distributed chondrocytes.Chondrocyte apoptosis is one of the programmed cell death modalities of chondrocytes.During the normal physiological process,the proliferation and apoptosis of chondrocytes maintain a dynamic equilibrium,jointly safeguarding the homeostasis of articular cartilage.However,in the osteoarthritis process,the stimulation of related cytokines after tissue damage induces an imbalance between chondrocyte proliferation and apoptosis,resulting in excessive chondrocyte apoptosis,and subsequently leading to the degradation and degeneration of cartilage.Clinically,traditional Chinese medicine and its related therapeutic approaches remain one of the principal means for treating osteoarthritis in China.The traditional Chinese medicine,which are bioactive compounds extracted from traditional herbal medicines,has gradually gained recognition thanks to their convenient to take and remarkable therapeutic effect.Therefore,this review takes the signaling pathways involved in the inhibition of chondrocyte apoptosis by traditional Chinese medicine as the entry point,systematically retrieves and screens and summarizes relevant studies at home and abroad in the past five years,and analyzes the mechanism of action of related signaling pathways in the treatment of chondrocyte apoptosis in osteoarthritis by traditional Chinese Medicine,providing new options for the pharmacological treatment of osteoarthritis.关键词
骨关节炎/软骨细胞凋亡/中药单体/信号通路Key words
Osteoarthritis/Chondrocyte apoptosis/Traditional Chinese medicine monomers/Signal pathway分类
医药卫生引用本文复制引用
王唯任,康斯文,魏巍,周广智,邰东旭..中药单体治疗骨关节炎中软骨细胞凋亡相关信号通路的研究进展[J].世界科学技术-中医药现代化,2025,27(11):3183-3195,13.基金项目
辽宁省科学技术厅项目应用基础研究计划(2022JH2/101300095):基于脏象理论"肝主筋,肾主骨"探究补正续骨丸通过Nrf2/GPX4调控骨关节炎软骨细胞铁死亡机制,负责人:邰东旭 （2022JH2/101300095）
辽宁省科学技术厅项目应用基础研究计划(2023JH2/101700222):负载桃叶珊瑚苷和SMT的ZIF-8纳米颗粒靶向骨关节炎滑膜巨噬细胞代谢重编程的效应研究,负责人:康斯文. （2023JH2/101700222）
