生命科学研究2025，Vol.29Issue(5)：389-397,9.DOI:10.16605/j.cnki.1007-7847.2025.02.0119
Lachnoclostridium介导膳食豆类摄入量与血脂水平的关联
Lachnoclostridium Mediates the Association Between Dietary Legume Intake and Blood Lipid Levels
摘要
Abstract
This study aimed to investigate the relationship between dietary legume intake and blood lipid levels in adults with dyslipidemia or borderline elevated lipid levels,and to assess the mediating effect of gut microbes in this association.From May 2023 to May 2024,a total of 436 community-dwelling residents in Guangzhou,China,with dyslipidemia or borderline elevated lipid levels,were recruited.Differences in gut microbiota were determined using 16S rRNA high-throughput sequencing.The relationship between dietary legume intake and blood lipid levels was analyzed using multiple linear regression.The dietary legume in-take related genera in gut microbes were detected using microbiome multivariable linear models,and the mediating effects of gut microbes were assessed by mediation analysis.The results showed that,after adjusting for the confounders,dietary legume intake was significantly negatively associated with total cholesterol(β=-0.010,P＜0.050)and low-density lipoprotein cholesterol(β=-0.012,P＜0.050).A total of 21 genera were found to be significantly associated with dietary legume intake(q＜0.250).Among them,Lachnoclostridium exhibited a significant mediating effect on the negative association between dietary legume intake and low-density lipoprotein cholesterol levels(P=0.048).This study provides a theoretical foundation for the effective manage-ment of lipid levels in individuals with dyslipidemia or borderline elevated lipid levels.关键词
膳食豆类摄入量/血脂水平/肠道微生物/LachnoclostridiumKey words
dietary legume intake/lipid level/gut microbe/Lachnoclostridium分类
生物学引用本文复制引用
李广,冯浩,徐艺萱,肖苏妹,张云,任茂鑫,张琼,邓艳君,崔宇豪,黄佳美,杨唯依,王小宝..Lachnoclostridium介导膳食豆类摄入量与血脂水平的关联[J].生命科学研究,2025,29(5):389-397,9.基金项目
国家自然科学基金资助项目(81400857) （81400857）
广东省自然科学基金项目(2021A1515011527) （2021A1515011527）
广州市珠江科技新星计划项目(201610010093) （201610010093）
