生命科学研究2025，Vol.29Issue(5)：398-405,8.DOI:10.16605/j.cnki.1007-7847.2025.02.0121
DNA甲基化在心肌肥大发生中的研究进展
Research Progress on DNA Methylation in the Pathogenesis of Cardiac Hypertrophy
摘要
Abstract
Cardiac hypertrophy is a process of cardiac adaptive and pathological remodeling,which is usually closely related to increased cardiac workload,chronic stress,and occurrence and development of heart di-sease.In recent years,the role of DNA methylation in cardiac hypertrophy and dysfunction has received ex-tensive attention as an important epigenetic modification mechanism.This article reviews the mechanism of DNA methylation in cardiac hypertrophy and explores its potential effects on cardiac development,gene ex-pression regulation and disease treatment,aiming to provide a new theoretical basis and potential interven-tion targets for the prevention and treatment of cardiac hypertrophy.关键词
心肌肥大/DNA甲基化/DNA甲基化酶/DNA甲基化酶抑制剂Key words
cardiac hypertrophy/DNA methylation/DNA methyltransferase(DNMT)/DNMT inhibitor分类
生物科学引用本文复制引用
易可馨,刘欣,吴秀山,李永青..DNA甲基化在心肌肥大发生中的研究进展[J].生命科学研究,2025,29(5):398-405,8.基金项目
湖南省研究生科研创新项目(CX20230526) （CX20230526）
