生命科学研究2025，Vol.29Issue(5)：406-412,7.DOI:10.16605/j.cnki.1007-7847.2025.03.0126
肠道微生物群影响精神分裂症发生发展的作用机制
The Mechanism by Which the Gut Microbiota Affects the Occurrence and Development of Schizophrenia
摘要
Abstract
The diversity,composition and functional capacity of the gut microbiota vary considerably among individuals,and these differences have been shown to be related to the occurrence and development of various diseases.Schizophrenia is the most serious,disabling,and devastating of all mental diseases,yet its etiology and pathogenesis remain poorly understood.This paper mainly discusses the correlation between intestinal microbes and schizophrenia,as well as the possible mechanisms of action,such as kynurenine metabolic pathway,synaptic plasticity,and infection and inflammation,so as to provide insights for the prevention and treatment of mental illnesses.关键词
肠道微生物群/精神分裂症/犬尿氨酸代谢途径/感染与炎症/突触可塑性Key words
gut microbiota/schizophrenia/kynurenine metabolic pathway/infection and inflammation/sy-naptic plasticity分类
生物学引用本文复制引用
谭志霞,刘媛淇,杨霖娜,彭怡,张毕明,叶湘漓..肠道微生物群影响精神分裂症发生发展的作用机制[J].生命科学研究,2025,29(5):406-412,7.基金项目
湖南省卫生健康委员会重点项目(202201065690) （202201065690）
长沙市卫生健康委员会科研项目(KJ-B2023101) （KJ-B2023101）
长沙市自然科学基金项目(kq2502320) （kq2502320）
