实用妇产科杂志2025，Vol.41Issue(10)：847-851,5.
褪黑素对高龄卵巢储备功能减退不孕患者体外受精-胚胎移植妊娠结局的影响
Effect of Melatonin on IVF-ET Pregnancy Outcome in Elderly Infertile Patients with Diminished Ovarian Reserve
摘要
Abstract
Objective:To evaluate the impact of oral melatonin on clinical pregnancy outcomes in elderly infer-tile patients with diminished ovarian reserve(DOR)after in vitro fertilization and embryo transfer(IVF-ET).Methods:Sixty-two elderly infertile patients with DOR who underwent IVF at the Reproductive Medicine Center of Qinghai Province People's Hospital from January 1,2022 to June 30,2023 were selected.They were divided into intervention group(24 cases)and control group(38 cases)according to whether they received oral melatonin pretreatment before ovulation induction.Follicular fluid without diluent or blood contamination was collected from the first large follicle on the day of oocyte retrieval,and melatonin levels and 8-hydroxy-2'-deoxyglycoside(8-OHdG)levels in the follicular gluid were measured.Ovulation promotion indicators and pregnancy outcomes were compared and analyzed between the two groups.Results:The concentration of melatonin in follicular fluid in the intervention group was significantly higher than that in the control group(31.75 ng/L vs.10.40 ng/L,P＜0.001),the concentration of 8-OHdG was lower than that of the control group(133.61 ng/L vs.145.30 ng/L,P=0.004);the implantation rate in the intervention group was significantly higher than that in the control group(56.10％vs.26.87％,P=0.002),and the biochemical pregnancy rate in the intervention group was significantly higher than that in the control group(12.50％vs.0,P=0.050).There were no significant differences in normal fertilization rate,high-quality embryo rate,clinical pregnancy rate and cumulative live birth rate between the two groups(P＞0.05).Conclusions:Oral melatonin can increase its level in follicular fluid,which is beneficial in improving endom-etrial receptivity,and has a certain positive effect on improving IVF-ET outcomes.关键词
褪黑素/高龄/卵巢储备功能减退/不孕/体外受精-胚胎移植Key words
Melatonin/Advanced age/Impaired ovarian reserve/Infertility/In vitro fertilization and embryo transfer分类
基础医学引用本文复制引用
简生燕,马荣花,李晓娜,吕金春,黄青莉,熊正方..褪黑素对高龄卵巢储备功能减退不孕患者体外受精-胚胎移植妊娠结局的影响[J].实用妇产科杂志,2025,41(10):847-851,5.基金项目
青海省卫生健康委科研课题(编号:2021-wjzdx-13) （编号:2021-wjzdx-13）
