实用妇产科杂志2025，Vol.41Issue(10)：859-864,6.
子宫内膜癌淋巴结转移相关危险因素分析及预测模型的构建
Analysis of Risk Factors Associated with Lymph Node Metastasis in Endome-trial Cancer and Construction of a Predictive Model
吴滟泓 1朱明玥 1付霞霏 1毛梦丽 1谢钰彤 2王沂峰 1彭冬先 1杨进 1马颖 1朱洪磊 1韩娜娜1
作者信息
- 1. 南方医科大学珠江医院妇产科,广东 广州 510280
- 2. 广州医科大学第二临床医学院,广东 广州 511436
- 折叠
摘要
Abstract
Objective:To explore the relationship between general demographic characteristics,inflammatory indicators,nutritional indicators,pathological data and lymph node metastasis in endometrial cancer(EC)pa-tients,and to construct and validate a model for preoperative prediction of lymph node status in endometrial canc-er patients.Methods:The preoperative clinical data of 473 patients with EC who underwent surgical treatment in the Zhu Jiang Hospital of Southern Medical University from January 2010 to April 2024 were retrospectively ana-lyzed.The independent risk factors of lymph node metastasis of endometrial cancer were screened by univariate and multivariate Logistic regression analyses,and the nomogram prediction model was constructed by R soft-ware.The performance of the model was evaluated by the receiver operating characteristic(ROC)curve,calibra-tion curve and clinical decision curve.Results:Menopausal status,high grade biopsy pathology,CA125 ≥24.47U/ml,systemic immune inflammatory index(SII)≥710.91,and prognostic nutritional index(PNI)＜52.90 were in-dependent risk factors for lymph node metastasis in endometrial cancer(OR＞1,P＜0.05).The nomogram model constructed based on these five factors had an AUC of 0.853 in the training set and 0.871 in the test set.The cali-bration curve fitted well,and the clinical decision curve shows a positive benefit.Conclusions:The endometrial cancer lymph node metastasis prediction model constructed based on menopausal status,biopsy pathology,CA125,SII,and PNI has good accuracy and fit,with certain clinical application value.关键词
子宫内膜癌/淋巴结转移/炎症指标/预测模型/列线图Key words
Endometrial cancer/Lymph node metastasis/Inflammatory markers/Predictive model/Nomogram分类
临床医学引用本文复制引用
吴滟泓,朱明玥,付霞霏,毛梦丽,谢钰彤,王沂峰,彭冬先,杨进,马颖,朱洪磊,韩娜娜..子宫内膜癌淋巴结转移相关危险因素分析及预测模型的构建[J].实用妇产科杂志,2025,41(10):859-864,6.
