摘要
Abstract
Objective:To investigate the efficacy and safety of ultrasound-guided stellate ganglion block(SGB)in the treatment of insomnia.Methods:A randomized double-blind controlled trial design was conducted on 110 patients with insomnia admitted to Xuchang Longhu Hospital from Aug 2021 to Sep 2024.The patients were assigned into the control group and the observation group according to a random number table method,with 55 cases in each group.The control group received traditional blind puncture SGB treatment,while the observation group received ultrasound-guided SGB treatment.They were all treated for 7 days.The scores of each item of Pittsburgh sleep quality index(PSQI)and total score,cerebral blood flow parameters[resistance index(RI),peak systolic velocity(PKV),time average velocity(TAV)of common carotid and vertebral arteries],the levels of serum neurotransmitters[norepinephrine(NE),5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF),gamma-aminobutyric acid(GABA)]before and after treatment,as well as clinical efficacy and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the total incidence of adverse reactions was lower than that in the control group(P＜0.05).After treatment,the subjective sleep quality,time to fall asleep,sleep duration,daytime dysfunction,hypnotic medication,sleep disturbance,sleep efficiency scores,and total score of PSQI in both groups decreased,with a more significant decrease in the observation group(P＜0.05).After treatment,the RI and PKV of the common carotid artery and vertebral artery decreased,and the TAV increased in both groups,with a more significant improvement in the observation group(P＜0.05).Compared with the control group,the NE level decreased,while 5-HT,BDNF,and GABA levels increased in the observation group after treatment(P＜0.05).Conclusion:Ultrasound-guided SGB has significant effects on insomnia patients,which can improve sleep quality,improve cerebral hemodynamics and neurotransmitter levels,and is safe.关键词
失眠症/超声引导/星状神经节阻滞/匹兹堡睡眠质量指数/脑血流参数Key words
insomnia/ultrasound guidance/stellate ganglion block/Pittsburgh Sleep Quality Index/cerebral blood flow parameters分类
医药卫生
