实用医学杂志2025，Vol.41Issue(22)：3474-3479,6.DOI:10.3969/j.issn.1006-5725.2025.22.002
3种治疗方案对薄型子宫内膜患者冻融胚胎移植临床结局的影响
Clinical outcomes of three treatment protocols for frozen-thawed embryo transfer in patients with thin endometrium
摘要
Abstract
Objective To compare the clinical pregnancy outcomes of tamoxifen(TAM),TAM combined with intrauterine perfusion of platelet-rich plasma(PRP),and hormone replacement therapy(HRT)combined with intrauterine perfusion of PRP for frozen-thawed embryo transfer(FET)in patients with thin endometrium.Methods A retrospective analysis was performed on clinical data of 321 patients with thin endometrium(endome-trial thickness≤7 mm in previous cycles)who underwent FET at the Reproductive Medicine Center of Guangdong Provincial Reproductive Hospital from January 2023 to April 2025.According to the treatment protocols,the patients were divided into three groups:TAM group(Group A,n=98),TAM+PRP group(Group B,n=91),and HRT+PRP group(Group C,n=132).General information,endometrial thickness on the conversion day before and after treatment,clinical pregnancy outcomes,andcosts of endometrial preparation treatment were com-pared among the three groups.Results There were no significant differences in age,duration of infertility,type of infertility,anti-Müllerian hormone(AMH)level,basal follicle-stimulating hormone(FSH)among the three groups(P>0.05).After treatment,there were no significant differences in endometrial thickness on the conversion day or the extent of increase among the three groups(P>0.05).The clinical pregnancy rates in Group A,Group B,and Group C were 56.1%,51.6%,and 43.2%respectively,with a significant difference(P=0.011);the embryo implantation rates were 43.6%,45.5%,and 34.6%respectively,showing a significant difference(P=0.019).The early abortion rate in Group A(3.64%)was significantly lower than that in Group C(15.79%)(P<0.01).In terms of treatment cost of endometrial preparation treatment,the cost in Group A(676.5±494.5 Yuan)was significantly lower than that in Group B(2 401.2±764.2 Yuan)and Group C(3 093.8±758.3 Yuan)(P<0.01).Conclusion In FET cycles for patients with thin endometrium,the clinical outcomes of TAM,TAM+PRP and HRT+PRP are comparable,and TAM demonstrates advantages in terms of a lower early miscarrage rate and better cost-effectiveness,thus serving as an option for endometrial preparation in patients with thin endometrium.关键词
薄型子宫内膜/他莫昔芬/富血小板血浆/激素替代治疗/宫腔灌注Key words
thin endometrium/tamoxifen/platelet-rich plasma/hormone replacement therapy/intrauterine perfusion分类
临床医学引用本文复制引用
马从顺,崔媛媛,朱婉珊,詹雪君,谭颖..3种治疗方案对薄型子宫内膜患者冻融胚胎移植临床结局的影响[J].实用医学杂志,2025,41(22):3474-3479,6.基金项目
广东省医学科研基金项目(编号:A2025073) （编号:A2025073）
