生殖医学杂志2025，Vol.34Issue(11)：1451-1456,6.DOI:10.3969/j.issn.1004-3845.2025.11.001
囊胚质量对冻融单囊胚移植临床结局与新生儿结局的影响
Effects of blastocyst quality on clinical outcomes and neonatal outcomes in frozen-thawed single blastocyst transfer
摘要
Abstract
Objectives:To investigate the potential impact of blastocyst quality on clinical pregnancy and neonatal outcome in patients undergoing freeze-thawed embryo transfer(FET)with single blastocyst. Methods:The clinical data of 15 660 FET cycles with single blastocyst at The ART Center of Northwest Women's and Children's Hospital from January 2015 to November 2024 were retrospectively analyzed.The patients were divided into three groups according to the quality of blastocysts:high-quality blastocysts group(group A,9 681 cycles),intermediate-quality blastocysts group(group B,4 395 cycles),and low-quality blastocysts group(group C,1 584 cycles).General characteristics,pregnancy outcomes,and neonatal outcomes were compared among the three groups.A multivariate logistic regression analysis was then applied to evaluate the relationship between blastocyst quality and pregnancy outcomes. Results:There were significant differences in age(age at FET and oocyte retrieval),female body mass index(BMI),infertility duration,the infertility type,the infertility cause,the fertilization method,number of two pronuclei(2PN),endometrial preparation protocol,number of FET cycles,proportion of blastocysts at different stages among the three groups(P＜0.05).There were significant differences in the clinical pregnancy rate(68.3％vs.56.5％vs.42.6％)and live birth rate(57.2％vs.44.5％vs.33.3％)among the three groups compared pairwise(P＜0.05).The early miscarriage rates of group B and C were significantly higher than that of group A(17.4％、17.8％vs.12.7％,P＜0.05).There were no significant differences in the percentage of preterm birth,low-birth-weight newborn and macrosomia among the three groups(P＞0.05),but there was a higher rate of male fetus births in group A when compared with the other two groups(P＜0.05).The logistic regression model adjusted for female age at FET and oocyte retrieval,female BMI,number of FET cycles,endometrial preparation protocol and then lower clinical pregnancy and live birth rates were found in the other two groups when compared with group A(P＜0.001). Conclusions:Blastocysts quality significantly affects the clinical pregnancy rate,and the rate of live births,but it has no significant effect on the birth weight and premature birth rate of newborns.关键词
囊胚质量/冻融单囊胚移植/临床妊娠率/活产率Key words
Blastocyst quality/Frozen-thawed single blastocyst transfer/Clinical pregnancy rate/Live birth rate分类
医药卫生引用本文复制引用
闫学花,张凡,高飞强,刘小华,薛侠,师娟子..囊胚质量对冻融单囊胚移植临床结局与新生儿结局的影响[J].生殖医学杂志,2025,34(11):1451-1456,6.基金项目
陕西省卫生健康生殖医学科研创新团队(2023-ZDLSF-48) （2023-ZDLSF-48）
