生殖医学杂志2025，Vol.34Issue(11)：1508-1512,5.DOI:10.3969/j.issn.1004-3845.2025.11.009
多发性子宫内膜息肉患者行宫腔镜下子宫内膜息肉切除术前地屈孕酮预处理的临床疗效观察
Clinical efficacy of dydrogesterone pretreatment before transcervical resection of endometrial polyps in patients with multiple endometrial polyps
摘要
Abstract
Objectives:To preliminary investigate the effect of dydrogesterone pretreatment before transcervical resection of endometrial polyps(TCRP)on the recurrence rate and clinical efficacy in patients with multiple endometrial polyps. Methods:A retrospective analysis was conducted on the clinical data of 166 patients with multiple endometrial polyps admitted to the Third Affiliated Hospital of Nanjing Medical University(Changzhou Second People's Hospital)from January 2022 to June 2024.According to different preoperative pretreatment methods,the patients were divided into three groups:group A(dydrogesterone pretreatment for one cycle,42 cases),group B(dydrogesterone pretreatment for two cycles,28 cases),and group C(control group with no pretreatment,96 cases).The therapeutic effect of progesterone pretreatment was evaluated through clinical data comparison. Results:There was no significant difference in general characteristics among the three groups(P＞0.05).The preoperative endometrial thickness in group B was significantly lower than that of group C[(0.83±0.28)cm vs.(1.06±0.35)cm,P＜0.05],and the duration of postoperative vaginal bleeding of group A was significantly shorter than that of group C[(4.74±1.36)d vs.(5.32±2.00)d,P＜0.05].The total effective rates of treatment in group A and group B were significantly higher than that in group C(85.71％,100.00％vs.66.67％,P＜0.05).The postoperative polyp recurrence rate in group B was significantly lower than that in group C(0.00％vs.13.54％,P＜0.05). Conclusions:Pretreatment with dydrogesterone before TCRP may play a certain role in optimizing the treatment of patients with multiple endometrial polyps,but its long-term efficacy still needs further research and verification.关键词
多发性子宫内膜息肉/宫腔镜/地屈孕酮/预处理Key words
Multiple endometrial polyps/Hysteroscope/Dydrogesterone/Pretreatment分类
临床医学引用本文复制引用
薛文芃,毛惠,陈继明,邢庭玮,魏炜炜,徐琳,曹颖,虞意,余柳杉,钟兴艳,杨敏..多发性子宫内膜息肉患者行宫腔镜下子宫内膜息肉切除术前地屈孕酮预处理的临床疗效观察[J].生殖医学杂志,2025,34(11):1508-1512,5.基金项目
中国医药卫生事业发展基金会资助课题(BJ2023YCPYJH003) （BJ2023YCPYJH003）
常州市卫生健康人才国外研修资助项目(GW2023024) （GW2023024）
常州市"十四五"卫生健康高层次人才培养工程(2022CZBJ074) （2022CZBJ074）
江苏省妇幼健康科研项目(F202138) （F202138）
常州市卫健委科技项目重大项目(ZD202314) （ZD202314）
